A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge: A spectroscopic and theoretical investigation

Özlen F. Erdem, Lennart Schwartz, Matthias Stein, Alexey Silakov, Sandeep Kaur-Ghumaan, Ping Huang, Sascha Ott, Edward J. Reijerse, Wolfgang Lubitz

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Convincing evidence for the presence of a nitrogen atom in the dithiolate bridge of the active site of native [FeFe] hydrogenases (B) is provided by a spectroscopic, electrochemical, and theoretical study of a well-characterized structural mimic of the [FeFe] hydrogenase subcluster (picture: 14N matched-HYSCORE spectrum of the model compound A). This result should help to understand the mechanism of dihydrogen conversion and production.

Original languageEnglish (US)
Pages (from-to)1439-1443
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number6
DOIs
StatePublished - Feb 7 2011

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Hydrogenase
Nitrogen
Atoms

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Erdem, Özlen F. ; Schwartz, Lennart ; Stein, Matthias ; Silakov, Alexey ; Kaur-Ghumaan, Sandeep ; Huang, Ping ; Ott, Sascha ; Reijerse, Edward J. ; Lubitz, Wolfgang. / A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge : A spectroscopic and theoretical investigation. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 6. pp. 1439-1443.
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A model of the [FeFe] hydrogenase active site with a biologically relevant azadithiolate bridge : A spectroscopic and theoretical investigation. / Erdem, Özlen F.; Schwartz, Lennart; Stein, Matthias; Silakov, Alexey; Kaur-Ghumaan, Sandeep; Huang, Ping; Ott, Sascha; Reijerse, Edward J.; Lubitz, Wolfgang.

In: Angewandte Chemie - International Edition, Vol. 50, No. 6, 07.02.2011, p. 1439-1443.

Research output: Contribution to journalArticle

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