A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological reactivity of most human sera

Zhaohui Wang, Neil Christensen, John T. Schiller, Joakim Dillner

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

A type-specific and neutralizing mouse MAb (V5) against human papillomavirus (HPV) type 16 capsids was found to block the serological reactivity of human sera with the corresponding capsids. Out of 352 human serum samples tested for the presence of IgG against HPV-16, more than 75% of reactive sera were completely blocked by the V5 antibody. Type-specific MAbs against HPV-6, -18 and -33 were also found to block serological reactivity with capsids of the corresponding HPV types for the majority of reactive human sera. The results suggest that most antibodies in human sera that are reactive with intact HPV capsids recognize the same or closely related major antigenic determinant(s).

Original languageEnglish (US)
Pages (from-to)2209-2215
Number of pages7
JournalJournal of General Virology
Volume78
Issue number9
DOIs
StatePublished - Sep 1997

Fingerprint

Human papillomavirus 16
Capsid
Monoclonal Antibodies
Serum
Human papillomavirus 6
Human papillomavirus 18
Antibodies
Epitopes
Immunoglobulin G

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

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abstract = "A type-specific and neutralizing mouse MAb (V5) against human papillomavirus (HPV) type 16 capsids was found to block the serological reactivity of human sera with the corresponding capsids. Out of 352 human serum samples tested for the presence of IgG against HPV-16, more than 75{\%} of reactive sera were completely blocked by the V5 antibody. Type-specific MAbs against HPV-6, -18 and -33 were also found to block serological reactivity with capsids of the corresponding HPV types for the majority of reactive human sera. The results suggest that most antibodies in human sera that are reactive with intact HPV capsids recognize the same or closely related major antigenic determinant(s).",
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A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological reactivity of most human sera. / Wang, Zhaohui; Christensen, Neil; Schiller, John T.; Dillner, Joakim.

In: Journal of General Virology, Vol. 78, No. 9, 09.1997, p. 2209-2215.

Research output: Contribution to journalArticle

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