A multi-center randomized trial of two different intravenous fluids during labor

Lisa M. Dapuzzo-Argiriou, John C. Smulian, Meredith L. Rochon, Luisa Galdi, Jessika M. Kissling, Peter F. Schnatz, Angel Gonzalez Rios, James Airoldi, Mary Anne Carrillo, Jaimie Maines, Allen Kunselman, John Repke, Richard Legro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.Methods: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.Results: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.Conclusions: The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume29
Issue number2
DOIs
StatePublished - Jan 17 2016

Fingerprint

Glucose
Dilatation
Birth Rate
Internship and Residency
Obstetrics
Maintenance
Mothers
Demography
Ringer's lactate

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Dapuzzo-Argiriou, L. M., Smulian, J. C., Rochon, M. L., Galdi, L., Kissling, J. M., Schnatz, P. F., ... Legro, R. (2016). A multi-center randomized trial of two different intravenous fluids during labor. Journal of Maternal-Fetal and Neonatal Medicine, 29(2), 191-196. https://doi.org/10.3109/14767058.2014.998190
Dapuzzo-Argiriou, Lisa M. ; Smulian, John C. ; Rochon, Meredith L. ; Galdi, Luisa ; Kissling, Jessika M. ; Schnatz, Peter F. ; Gonzalez Rios, Angel ; Airoldi, James ; Carrillo, Mary Anne ; Maines, Jaimie ; Kunselman, Allen ; Repke, John ; Legro, Richard. / A multi-center randomized trial of two different intravenous fluids during labor. In: Journal of Maternal-Fetal and Neonatal Medicine. 2016 ; Vol. 29, No. 2. pp. 191-196.
@article{f9a266092b6746a49004d7f5c121dd2d,
title = "A multi-center randomized trial of two different intravenous fluids during labor",
abstract = "Objective: To determine if the intrapartum use of a 5{\%} glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.Methods: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5{\%} glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.Results: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0{\%}) versus the LR arm (18/156 or 11.5{\%}), [RR (95{\%} CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.Conclusions: The use of intravenous fluid containing 5{\%} dextrose does not lower the chance of cesarean delivery for women admitted in active labor.",
author = "Dapuzzo-Argiriou, {Lisa M.} and Smulian, {John C.} and Rochon, {Meredith L.} and Luisa Galdi and Kissling, {Jessika M.} and Schnatz, {Peter F.} and {Gonzalez Rios}, Angel and James Airoldi and Carrillo, {Mary Anne} and Jaimie Maines and Allen Kunselman and John Repke and Richard Legro",
year = "2016",
month = "1",
day = "17",
doi = "10.3109/14767058.2014.998190",
language = "English (US)",
volume = "29",
pages = "191--196",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "2",

}

Dapuzzo-Argiriou, LM, Smulian, JC, Rochon, ML, Galdi, L, Kissling, JM, Schnatz, PF, Gonzalez Rios, A, Airoldi, J, Carrillo, MA, Maines, J, Kunselman, A, Repke, J & Legro, R 2016, 'A multi-center randomized trial of two different intravenous fluids during labor', Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, no. 2, pp. 191-196. https://doi.org/10.3109/14767058.2014.998190

A multi-center randomized trial of two different intravenous fluids during labor. / Dapuzzo-Argiriou, Lisa M.; Smulian, John C.; Rochon, Meredith L.; Galdi, Luisa; Kissling, Jessika M.; Schnatz, Peter F.; Gonzalez Rios, Angel; Airoldi, James; Carrillo, Mary Anne; Maines, Jaimie; Kunselman, Allen; Repke, John; Legro, Richard.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 29, No. 2, 17.01.2016, p. 191-196.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A multi-center randomized trial of two different intravenous fluids during labor

AU - Dapuzzo-Argiriou, Lisa M.

AU - Smulian, John C.

AU - Rochon, Meredith L.

AU - Galdi, Luisa

AU - Kissling, Jessika M.

AU - Schnatz, Peter F.

AU - Gonzalez Rios, Angel

AU - Airoldi, James

AU - Carrillo, Mary Anne

AU - Maines, Jaimie

AU - Kunselman, Allen

AU - Repke, John

AU - Legro, Richard

PY - 2016/1/17

Y1 - 2016/1/17

N2 - Objective: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.Methods: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.Results: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.Conclusions: The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.

AB - Objective: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.Methods: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.Results: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.Conclusions: The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.

UR - http://www.scopus.com/inward/record.url?scp=84983097831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983097831&partnerID=8YFLogxK

U2 - 10.3109/14767058.2014.998190

DO - 10.3109/14767058.2014.998190

M3 - Article

VL - 29

SP - 191

EP - 196

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 2

ER -

Dapuzzo-Argiriou LM, Smulian JC, Rochon ML, Galdi L, Kissling JM, Schnatz PF et al. A multi-center randomized trial of two different intravenous fluids during labor. Journal of Maternal-Fetal and Neonatal Medicine. 2016 Jan 17;29(2):191-196. https://doi.org/10.3109/14767058.2014.998190