@article{f833ee8c67e64f7ebbdbef5d60eea88a,
title = "A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations",
abstract = "Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. Ktrans, ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known Ktrans and ve values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain Ktrans and ve kinetic trends across algorithms. Algorithms performed well (less than 3% average error) when no noise was present in the DRO. With noise, 87% of Ktrans and 84% of ve algorithm-DRO combinations were generally in the correct order. Low Krippendorff's alpha values showed that algorithms could not consistently classify patients as above or below the median for a given algorithm at each time point or for differences in values between time points. A majority of the algorithms produced a significant Spearman correlation in ve of the primary gross tumor volume with time. Algorithmic differences in Ktrans and ve values over time indicate limitations in combining/comparing data from distinct DCE-MRI model implementations. Careful cross-algorithm quality-assurance must be utilized as DCE-MRI results may not be interpretable using differing software.",
author = "Ger, {Rachel B.} and Mohamed, {Abdallah S.R.} and Awan, {Musaddiq J.} and Yao Ding and Kimberly Li and Fave, {Xenia J.} and Beers, {Andrew L.} and Brandon Driscoll and Hesham Elhalawani and Hormuth, {David A.} and Houdt, {Petra J.Van} and Renjie He and Shouhao Zhou and Mathieu, {Kelsey B.} and Heng Li and Catherine Coolens and Caroline Chung and Bankson, {James A.} and Wei Huang and Jihong Wang and Sandulache, {Vlad C.} and Lai, {Stephen Y.} and Howell, {Rebecca M.} and Stafford, {R. Jason} and Yankeelov, {Thomas E.} and Heide, {Uulke A.Van Der} and Frank, {Steven J.} and Barboriak, {Daniel P.} and Hazle, {John D.} and Court, {Laurence E.} and Jayashree Kalpathy-Cramer and Fuller, {Clifton D.}",
note = "Funding Information: Multiple funders/agencies contributed to contributing personnel salary or project support during the study execution and manuscript preparation interval. Drs. Lai, Mohamed and Fuller receive funding support from the National Institutes of Health (NIH)/National Institute for Dental and Craniofacial Research (NIDCR) (R01DE025248). Dr. Fuller received/(s) grant and/or salary support from the NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Career Development Award (P50CA097007-10); the NCI Paul Calabresi Clinical Oncology Program Award (K12 CA088084-06); a General Electric Healthcare/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award; an Elekta AB/MD Anderson Department of Radiation Oncology Seed Grant; the Center for Radiation Oncology Research (CROR) at MD Anderson Cancer Center Seed Grant; the MD Anderson Institutional Research Grant (IRG) Program; and the NIH/NCI Cancer Center Support (Core) Grant CA016672 to The University of Texas MD Anderson Cancer Center (P30 CA016672). Rachel Ger is supported by the Rosalie B. Hite Graduate Fellowship in Cancer Research awarded by The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. Dr. Huang is funded by the NIH (U01 CA154602). Drs. Hormuth and Yankeelov are supported by the NIH (R01CA138599, U01CA174706) and Cancer Prevention Research Institute of Texas (CPRIT RR160005). Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-11554-w",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}