A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response

Casey McQuade, Ajlan Al Zaki, Yaanik Desai, Michael Vido, Timothy Sakhuja, Zhiliang Cheng, Andrew Tsourkas, Robert John Hickey, III, Daniel Joh, Gary Kao, Jay F. Dorsey, So Jung Park

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.

Original languageEnglish (US)
Pages (from-to)834-843
Number of pages10
JournalSmall
Volume11
Issue number7
DOIs
StatePublished - Feb 18 2015

Fingerprint

Radiotherapy
Global system for mobile communications
Gold
Imaging techniques
Nanoparticles
Tumors
Tomography
Magnetic resonance
Neoplasms
Micelles
Intravenous Injections
Bearings (structural)
Contrast Media
Irradiation
Magnetic Resonance Spectroscopy
Therapeutics
Magnetic Resonance Imaging
Iron oxides
Survival

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Engineering (miscellaneous)

Cite this

McQuade, C., Al Zaki, A., Desai, Y., Vido, M., Sakhuja, T., Cheng, Z., ... Park, S. J. (2015). A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. Small, 11(7), 834-843. https://doi.org/10.1002/smll.201401927
McQuade, Casey ; Al Zaki, Ajlan ; Desai, Yaanik ; Vido, Michael ; Sakhuja, Timothy ; Cheng, Zhiliang ; Tsourkas, Andrew ; Hickey, III, Robert John ; Joh, Daniel ; Kao, Gary ; Dorsey, Jay F. ; Park, So Jung. / A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. In: Small. 2015 ; Vol. 11, No. 7. pp. 834-843.
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McQuade, C, Al Zaki, A, Desai, Y, Vido, M, Sakhuja, T, Cheng, Z, Tsourkas, A, Hickey, III, RJ, Joh, D, Kao, G, Dorsey, JF & Park, SJ 2015, 'A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response', Small, vol. 11, no. 7, pp. 834-843. https://doi.org/10.1002/smll.201401927

A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. / McQuade, Casey; Al Zaki, Ajlan; Desai, Yaanik; Vido, Michael; Sakhuja, Timothy; Cheng, Zhiliang; Tsourkas, Andrew; Hickey, III, Robert John; Joh, Daniel; Kao, Gary; Dorsey, Jay F.; Park, So Jung.

In: Small, Vol. 11, No. 7, 18.02.2015, p. 834-843.

Research output: Contribution to journalArticle

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AU - Cheng, Zhiliang

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AU - Joh, Daniel

AU - Kao, Gary

AU - Dorsey, Jay F.

AU - Park, So Jung

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McQuade C, Al Zaki A, Desai Y, Vido M, Sakhuja T, Cheng Z et al. A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response. Small. 2015 Feb 18;11(7):834-843. https://doi.org/10.1002/smll.201401927