A multiscale computational model for the growth of the cranial vault in craniosynostosis

Research output: Contribution to conferencePaper

2 Citations (Scopus)

Abstract

Craniosynostosis is a condition defined by premature closure of cranial vault sutures, which is associated with abnormalities of the brain and skull. Many causal relationships between discovered mutations and premature suture closure have been proposed but an understanding of the precise mechanisms remains elusive. This article describes a computational framework of biological processes underlying cranial growth that will enable a hypothesis driven investigation of craniosynostosis phenotypes using reaction-diffusion-advection methods and the finite element method. Primary centers of ossification in cranial vault are identified using an activatorsubstrate model that represents the behavior of key molecules for bone formation. Biomechanical effects due to the interaction between growing bone and soft tissue is investigated to elucidate the mechanism of growth of cranial vault.

Original languageEnglish (US)
DOIs
StatePublished - Jan 1 2014
EventASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014 - Montreal, Canada
Duration: Nov 14 2014Nov 20 2014

Other

OtherASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014
CountryCanada
CityMontreal
Period11/14/1411/20/14

Fingerprint

Bone
Advection
Brain
Tissue
Finite element method
Molecules

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering

Cite this

Lee, C., Richtsmeier, J. T., & Kraft, R. H. (2014). A multiscale computational model for the growth of the cranial vault in craniosynostosis. Paper presented at ASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014, Montreal, Canada. https://doi.org/10.1115/IMECE2014-38728
Lee, Chanyoung ; Richtsmeier, Joan Therese ; Kraft, Reuben H. / A multiscale computational model for the growth of the cranial vault in craniosynostosis. Paper presented at ASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014, Montreal, Canada.
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Lee, C, Richtsmeier, JT & Kraft, RH 2014, 'A multiscale computational model for the growth of the cranial vault in craniosynostosis' Paper presented at ASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014, Montreal, Canada, 11/14/14 - 11/20/14, . https://doi.org/10.1115/IMECE2014-38728

A multiscale computational model for the growth of the cranial vault in craniosynostosis. / Lee, Chanyoung; Richtsmeier, Joan Therese; Kraft, Reuben H.

2014. Paper presented at ASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014, Montreal, Canada.

Research output: Contribution to conferencePaper

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AB - Craniosynostosis is a condition defined by premature closure of cranial vault sutures, which is associated with abnormalities of the brain and skull. Many causal relationships between discovered mutations and premature suture closure have been proposed but an understanding of the precise mechanisms remains elusive. This article describes a computational framework of biological processes underlying cranial growth that will enable a hypothesis driven investigation of craniosynostosis phenotypes using reaction-diffusion-advection methods and the finite element method. Primary centers of ossification in cranial vault are identified using an activatorsubstrate model that represents the behavior of key molecules for bone formation. Biomechanical effects due to the interaction between growing bone and soft tissue is investigated to elucidate the mechanism of growth of cranial vault.

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Lee C, Richtsmeier JT, Kraft RH. A multiscale computational model for the growth of the cranial vault in craniosynostosis. 2014. Paper presented at ASME 2014 International Mechanical Engineering Congress and Exposition, IMECE 2014, Montreal, Canada. https://doi.org/10.1115/IMECE2014-38728