Abstract

One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.

Original languageEnglish (US)
Article number43652
JournalScientific reports
Volume7
DOIs
StatePublished - Mar 8 2017

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Sudden Death
Malaria
Epilepsy
Infection
Cerebral Malaria
Animal Models
Parasites
Research

All Science Journal Classification (ASJC) codes

  • General

Cite this

Ssentongo, Paddy ; Robuccio, Anna E. ; Thuku, Godfrey ; Sim, Derek G. ; Nabi, Ali ; Bahari, Fatemeh ; Shanmugasundaram, Balaji ; Billard, Myles W. ; Geronimo, Andrew ; Short, Kurt W. ; Drew, Patrick J. ; Baccon, Jennifer ; Weinstein, Steven L. ; Gilliam, Frank G. ; Stoute, José A. ; Chinchilli, Vernon M. ; Read, Andrew F. ; Gluckman, Bruce J. ; Schiff, Steven J. / A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.",
author = "Paddy Ssentongo and Robuccio, {Anna E.} and Godfrey Thuku and Sim, {Derek G.} and Ali Nabi and Fatemeh Bahari and Balaji Shanmugasundaram and Billard, {Myles W.} and Andrew Geronimo and Short, {Kurt W.} and Drew, {Patrick J.} and Jennifer Baccon and Weinstein, {Steven L.} and Gilliam, {Frank G.} and Stoute, {Jos{\'e} A.} and Chinchilli, {Vernon M.} and Read, {Andrew F.} and Gluckman, {Bruce J.} and Schiff, {Steven J.}",
year = "2017",
month = "3",
day = "8",
doi = "10.1038/srep43652",
language = "English (US)",
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Ssentongo, P, Robuccio, AE, Thuku, G, Sim, DG, Nabi, A, Bahari, F, Shanmugasundaram, B, Billard, MW, Geronimo, A, Short, KW, Drew, PJ, Baccon, J, Weinstein, SL, Gilliam, FG, Stoute, JA, Chinchilli, VM, Read, AF, Gluckman, BJ & Schiff, SJ 2017, 'A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection', Scientific reports, vol. 7, 43652. https://doi.org/10.1038/srep43652

A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection. / Ssentongo, Paddy; Robuccio, Anna E.; Thuku, Godfrey; Sim, Derek G.; Nabi, Ali; Bahari, Fatemeh; Shanmugasundaram, Balaji; Billard, Myles W.; Geronimo, Andrew; Short, Kurt W.; Drew, Patrick J.; Baccon, Jennifer; Weinstein, Steven L.; Gilliam, Frank G.; Stoute, José A.; Chinchilli, Vernon M.; Read, Andrew F.; Gluckman, Bruce J.; Schiff, Steven J.

In: Scientific reports, Vol. 7, 43652, 08.03.2017.

Research output: Contribution to journalArticle

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T1 - A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection

AU - Ssentongo, Paddy

AU - Robuccio, Anna E.

AU - Thuku, Godfrey

AU - Sim, Derek G.

AU - Nabi, Ali

AU - Bahari, Fatemeh

AU - Shanmugasundaram, Balaji

AU - Billard, Myles W.

AU - Geronimo, Andrew

AU - Short, Kurt W.

AU - Drew, Patrick J.

AU - Baccon, Jennifer

AU - Weinstein, Steven L.

AU - Gilliam, Frank G.

AU - Stoute, José A.

AU - Chinchilli, Vernon M.

AU - Read, Andrew F.

AU - Gluckman, Bruce J.

AU - Schiff, Steven J.

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