A naturally occurring brominated furanone covalently modifies and inactivates LuxS

Tianzhu Zang, Bobby W.K. Lee, Lisa M. Cannon, Kathryn A. Ritter, Shujia Dai, Dacheng Ren, Thomas Keith Wood, Zhaohui Sunny Zhou

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).

Original languageEnglish (US)
Pages (from-to)6200-6204
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number21
DOIs
StatePublished - Nov 1 2009

Fingerprint

Bacteria LuxS protein
Rhodophyta
Quorum Sensing
Lyases
Biofilms
Algae
Biological Products
Enzymes
N-octanoylhomoserine lactone

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Zang, T., Lee, B. W. K., Cannon, L. M., Ritter, K. A., Dai, S., Ren, D., ... Zhou, Z. S. (2009). A naturally occurring brominated furanone covalently modifies and inactivates LuxS. Bioorganic and Medicinal Chemistry Letters, 19(21), 6200-6204. https://doi.org/10.1016/j.bmcl.2009.08.095
Zang, Tianzhu ; Lee, Bobby W.K. ; Cannon, Lisa M. ; Ritter, Kathryn A. ; Dai, Shujia ; Ren, Dacheng ; Wood, Thomas Keith ; Zhou, Zhaohui Sunny. / A naturally occurring brominated furanone covalently modifies and inactivates LuxS. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 21. pp. 6200-6204.
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A naturally occurring brominated furanone covalently modifies and inactivates LuxS. / Zang, Tianzhu; Lee, Bobby W.K.; Cannon, Lisa M.; Ritter, Kathryn A.; Dai, Shujia; Ren, Dacheng; Wood, Thomas Keith; Zhou, Zhaohui Sunny.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 21, 01.11.2009, p. 6200-6204.

Research output: Contribution to journalArticle

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