A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

Yu Chen Chen, Ning Xin Ma, Zi Fei Pei, Zheng Wu, Fabricio H. Do-Monte, Susan Keefe, Emma Yellin, Miranda S. Chen, Jiu Chao Yin, Grace Lee, Angélica Minier-Toribio, Yi Hu, Yu Ting Bai, Kathryn Lee, Gregory J. Quirk, Gong Chen

Research output: Contribution to journalArticle

Abstract

After ischemic brain injury, many neurons die but surviving astrocytes become activated and proliferative. Using NeuroD1 AAV-based gene therapy, Chen and colleagues demonstrate robust neuroregeneration through direct astrocyte-to-neuron conversion and significantly improved functional recovery. This study provides a new paradigm for brain repair using in vivo cell conversion technology.

Original languageEnglish (US)
JournalMolecular Therapy
DOIs
StateAccepted/In press - Jan 1 2019

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Astrocytes
Genetic Therapy
Neurons
Wounds and Injuries
Brain
Brain Injuries
Technology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this

Chen, Yu Chen ; Ma, Ning Xin ; Pei, Zi Fei ; Wu, Zheng ; Do-Monte, Fabricio H. ; Keefe, Susan ; Yellin, Emma ; Chen, Miranda S. ; Yin, Jiu Chao ; Lee, Grace ; Minier-Toribio, Angélica ; Hu, Yi ; Bai, Yu Ting ; Lee, Kathryn ; Quirk, Gregory J. ; Chen, Gong. / A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion. In: Molecular Therapy. 2019.
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abstract = "After ischemic brain injury, many neurons die but surviving astrocytes become activated and proliferative. Using NeuroD1 AAV-based gene therapy, Chen and colleagues demonstrate robust neuroregeneration through direct astrocyte-to-neuron conversion and significantly improved functional recovery. This study provides a new paradigm for brain repair using in vivo cell conversion technology.",
author = "Chen, {Yu Chen} and Ma, {Ning Xin} and Pei, {Zi Fei} and Zheng Wu and Do-Monte, {Fabricio H.} and Susan Keefe and Emma Yellin and Chen, {Miranda S.} and Yin, {Jiu Chao} and Grace Lee and Ang{\'e}lica Minier-Toribio and Yi Hu and Bai, {Yu Ting} and Kathryn Lee and Quirk, {Gregory J.} and Gong Chen",
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Chen, YC, Ma, NX, Pei, ZF, Wu, Z, Do-Monte, FH, Keefe, S, Yellin, E, Chen, MS, Yin, JC, Lee, G, Minier-Toribio, A, Hu, Y, Bai, YT, Lee, K, Quirk, GJ & Chen, G 2019, 'A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion', Molecular Therapy. https://doi.org/10.1016/j.ymthe.2019.09.003

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion. / Chen, Yu Chen; Ma, Ning Xin; Pei, Zi Fei; Wu, Zheng; Do-Monte, Fabricio H.; Keefe, Susan; Yellin, Emma; Chen, Miranda S.; Yin, Jiu Chao; Lee, Grace; Minier-Toribio, Angélica; Hu, Yi; Bai, Yu Ting; Lee, Kathryn; Quirk, Gregory J.; Chen, Gong.

In: Molecular Therapy, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Pei, Zi Fei

AU - Wu, Zheng

AU - Do-Monte, Fabricio H.

AU - Keefe, Susan

AU - Yellin, Emma

AU - Chen, Miranda S.

AU - Yin, Jiu Chao

AU - Lee, Grace

AU - Minier-Toribio, Angélica

AU - Hu, Yi

AU - Bai, Yu Ting

AU - Lee, Kathryn

AU - Quirk, Gregory J.

AU - Chen, Gong

PY - 2019/1/1

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