A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

Yu Chen Chen, Ning Xin Ma, Zi Fei Pei, Zheng Wu, Fabricio H. Do-Monte, Susan Keefe, Emma Yellin, Miranda S. Chen, Jiu Chao Yin, Grace Lee, Angélica Minier-Toribio, Yi Hu, Yu Ting Bai, Kathryn Lee, Gregory J. Quirk, Gong Chen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

After ischemic brain injury, many neurons die but surviving astrocytes become activated and proliferative. Using NeuroD1 AAV-based gene therapy, Chen and colleagues demonstrate robust neuroregeneration through direct astrocyte-to-neuron conversion and significantly improved functional recovery. This study provides a new paradigm for brain repair using in vivo cell conversion technology.

Original languageEnglish (US)
JournalMolecular Therapy
DOIs
StateAccepted/In press - 2019

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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