A new age-structured multiscale model of the hepatitis C virus life-cycle during infection and therapy with direct-acting antiviral agents

Barbara de M. Quintela, Jessica M. Conway, James M. Hyman, Jeremie Guedj, Rodrigo W. dos Santos, Marcelo Lobosco, Alan S. Perelson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The dynamics of hepatitis C virus (HCV) RNA during translation and replication within infected cells were added to a previous age-structured multiscale mathematical model of HCV infection and treatment. The model allows the study of the dynamics of HCV RNA inside infected cells as well as the release of virus from infected cells and the dynamics of subsequent new cell infections. The model was used to fit in vitro data and estimate parameters characterizing HCV replication. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-structured multiscale modeling approach. Using this model we also studied the effects of direct-acting antiviral agents (DAAs) in blocking HCV RNA intracellular replication and the release of new virions and fit the model to in vivo data obtained from HCV-infected subjects under therapy.

Original languageEnglish (US)
Article number601
JournalFrontiers in Microbiology
Volume9
Issue numberAPR
DOIs
StatePublished - Apr 4 2018

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Life Cycle Stages
Hepacivirus
Antiviral Agents
Infection
RNA
Therapeutics
Virus Release
Virus Diseases
Virus Replication
Virion
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Quintela, Barbara de M. ; Conway, Jessica M. ; Hyman, James M. ; Guedj, Jeremie ; dos Santos, Rodrigo W. ; Lobosco, Marcelo ; Perelson, Alan S. / A new age-structured multiscale model of the hepatitis C virus life-cycle during infection and therapy with direct-acting antiviral agents. In: Frontiers in Microbiology. 2018 ; Vol. 9, No. APR.
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A new age-structured multiscale model of the hepatitis C virus life-cycle during infection and therapy with direct-acting antiviral agents. / Quintela, Barbara de M.; Conway, Jessica M.; Hyman, James M.; Guedj, Jeremie; dos Santos, Rodrigo W.; Lobosco, Marcelo; Perelson, Alan S.

In: Frontiers in Microbiology, Vol. 9, No. APR, 601, 04.04.2018.

Research output: Contribution to journalArticle

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