A new database of mitochondrial DNA hypervariable regions I and II sequences from 162 Japanese individuals

K. Imaizumi, T. J. Parsons, M. Yoshino, M. M. Holland

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

A database of mitochondrial DNA (mtDNA) hypervariable region 1 (HV1) and region 2 (HV2) sequences of the mtDNA control region was established from 162 unrelated Japanese individuals. The random match probability and the genetic diversity for this database were 0.96% and 0.997, respectively. Length heteroplasmy in the C-stretch regions located around position 16189 in HV1 and 310 in HV2 was observed in 37% and 38% of the samples, respectively. A strategy using internal sequencing primers was devised to obtain confirmed sequences in these length heteroplasmic individuals. This database, combined with other mtDNA sequence databases from the Japanese population, will permit the significance of mtDNA match results to be properly reported in mtDNA typing casework in Japan.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalInternational Journal of Legal Medicine
Volume116
Issue number2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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