A New Total Synthesis of the Fungal Toxin Slaframine

Richard A. Gobao; Martin L. Bremmer; Steven M. Weinreb

doi:10.1021/ja00389a030

A New Total Synthesis of the Fungal Toxin Slaframine

Richard A. Gobao, Martin L. Bremmer, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.

Original language	English (US)
Pages (from-to)	7065-7068
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	104
Issue number	25
DOIs	https://doi.org/10.1021/ja00389a030
State	Published - Jan 1 1982

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00389a030

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title = "A New Total Synthesis of the Fungal Toxin Slaframine",

abstract = "Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.",

author = "Gobao, {Richard A.} and Bremmer, {Martin L.} and Weinreb, {Steven M.}",

year = "1982",

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language = "English (US)",

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T1 - A New Total Synthesis of the Fungal Toxin Slaframine

AU - Gobao, Richard A.

AU - Bremmer, Martin L.

AU - Weinreb, Steven M.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.

AB - Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.

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DO - 10.1021/ja00389a030

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AN - SCOPUS:0020445799

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 25

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A New Total Synthesis of the Fungal Toxin Slaframine

Abstract

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