A New Total Synthesis of the Fungal Toxin Slaframine

Richard A. Gobao; Martin L. Bremmer; Steven M. Weinreb

doi:10.1021/ja00389a030

A New Total Synthesis of the Fungal Toxin Slaframine

Richard A. Gobao, Martin L. Bremmer, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article

56 Scopus citations

Abstract

Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.

Original language	English (US)
Pages (from-to)	7065-7068
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	104
Issue number	25
DOIs	https://doi.org/10.1021/ja00389a030
State	Published - Jan 1 1982

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00389a030

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Gobao, R. A., Bremmer, M. L., & Weinreb, S. M. (1982). A New Total Synthesis of the Fungal Toxin Slaframine. Journal of the American Chemical Society, 104(25), 7065-7068. https://doi.org/10.1021/ja00389a030

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abstract = "Slaframine (1) has been synthesized from diene aldehyde 2. An intramolecular imino Diels-Alder reaction has been used to produce the indolizidine skeleton and to establish the requisite stereochemistry of this fungal metabolite.",

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