A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically Patterned 6π-2-azatriene electrocyclization

Matthew L. Meketa, Steven M. Weinreb

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

(Chemical Equation Presented) A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6π-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalOrganic Letters
Volume9
Issue number5
DOIs
StatePublished - Mar 1 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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