A New View into the Regulation of Purine Metabolism

The Purinosome

Anthony M. Pedley, Stephen Benkovic

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell with the necessary energy and cofactors to promote cell survival and proliferation. A renewed interest in how purine metabolism may fuel cancer progression has uncovered a new perspective into how a cell regulates purine need. Under cellular conditions of high purine demand, the de novo purine biosynthetic enzymes cluster near mitochondria and microtubules to form dynamic multienzyme complexes referred to as ‘purinosomes’. In this review, we highlight the purinosome as a novel level of metabolic organization of enzymes in cells, its consequences for regulation of purine metabolism, and the extent that purine metabolism is being targeted for the treatment of cancers.

Original languageEnglish (US)
Pages (from-to)141-154
Number of pages14
JournalTrends in Biochemical Sciences
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2017

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Metabolism
Multienzyme Complexes
Mitochondria
Enzymes
Metabolites
purine
Microtubules
Neoplasms
Cell Survival
Cells
Cell Proliferation
RNA
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Pedley, Anthony M. ; Benkovic, Stephen. / A New View into the Regulation of Purine Metabolism : The Purinosome. In: Trends in Biochemical Sciences. 2017 ; Vol. 42, No. 2. pp. 141-154.
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A New View into the Regulation of Purine Metabolism : The Purinosome. / Pedley, Anthony M.; Benkovic, Stephen.

In: Trends in Biochemical Sciences, Vol. 42, No. 2, 01.02.2017, p. 141-154.

Research output: Contribution to journalReview article

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