A new xenotransplantation model reveals tumor-initiating cells in cutaneous squamous cell carcinoma

Research output: Contribution to journalComment/debate


Two articles by Patel et al. in this issue demonstrate reproducible, high-frequency xenografting of both primary human cutaneous squamous cell carcinoma (SCC) tissue and single-cell suspensions, as well as the existence of a small population of CD133 + tumor-initiating cells that are capable of regenerating the hierarchical organization and histology of the original tumor through multiple xenograft passages.

Original languageEnglish (US)
Pages (from-to)261-262
Number of pages2
JournalJournal of Investigative Dermatology
Issue number2
StatePublished - Feb 2012


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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