A new xenotransplantation model reveals tumor-initiating cells in cutaneous squamous cell carcinoma

Adam Glick

doi:10.1038/jid.2011.327

A new xenotransplantation model reveals tumor-initiating cells in cutaneous squamous cell carcinoma

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Two articles by Patel et al. in this issue demonstrate reproducible, high-frequency xenografting of both primary human cutaneous squamous cell carcinoma (SCC) tissue and single-cell suspensions, as well as the existence of a small population of CD133 ⁺ tumor-initiating cells that are capable of regenerating the hierarchical organization and histology of the original tumor through multiple xenograft passages.

Original language	English (US)
Pages (from-to)	261-262
Number of pages	2
Journal	Journal of Investigative Dermatology
Volume	132
Issue number	2
DOIs	https://doi.org/10.1038/jid.2011.327
State	Published - Feb 2012

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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abstract = " Two articles by Patel et al. in this issue demonstrate reproducible, high-frequency xenografting of both primary human cutaneous squamous cell carcinoma (SCC) tissue and single-cell suspensions, as well as the existence of a small population of CD133 + tumor-initiating cells that are capable of regenerating the hierarchical organization and histology of the original tumor through multiple xenograft passages.",

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