Two articles by Patel et al. in this issue demonstrate reproducible, high-frequency xenografting of both primary human cutaneous squamous cell carcinoma (SCC) tissue and single-cell suspensions, as well as the existence of a small population of CD133 + tumor-initiating cells that are capable of regenerating the hierarchical organization and histology of the original tumor through multiple xenograft passages.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology