A comparative study of Li2CuCl4 vs Li2CuCl3 mediated mono-coupling reactions of dihalide substrates with allylmangnesium bromide is reported. Higher yields were obtained with Li2CuCl3 and the following trends in halide reactivity were observed Br > Cl for alkyl, aryl, and thiophenyl dihalides. and benzyl halide > phenyl halide. Utilizing these trends, a symmetrical coupling procedure for alkyl. aryl benzyl and thiophenyl dihalides, simply carried out by combining the dihalide with metallic magnesium and Li2CuCl4 is reported.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry