A Novel Heterobifunctional Linker for Formyl to Thiol Coupling

Ned D. Heindel, Huiru Zhao, Roger A. Egolf, Chien Hsing Chang, Keith J. Schray, Jacqueline G. Emrich, Joanne P. McLaughlin, David V. Woo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A maleimide hydrazide has been synthesized as a heterobifunctional cross-linking agent for thiol to formyl coupling. This linker has been applied to the coupling of the monoclonal antibody 17–1A, or an Fab′ derived therefrom, to polyaldehyde dextran onto which the antineoplastic agent ellipticine has been attached. High binding avidities for the unshed antigen on the SW1116 colorectal tumor cell are retained in these drug-dextran-linker-antibody conjugates.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalBioconjugate Chemistry
Issue number6
StatePublished - May 1 1991

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A Novel Heterobifunctional Linker for Formyl to Thiol Coupling'. Together they form a unique fingerprint.

Cite this