The study of position and gesture of the work piece on the worktable of the manufacturing system is very important, especially in the material processing and manufacturing by using the laser technology. The position and gesture of the work piece of main traditional methods for the prior acquisition are to use the valuable contact and non-contact position measuring method. Which the methods the nifty system to obtain the strategic location information is less precise, run slow and cost more. This paper provided an electronic parallel datum processing and manufacturing measurement technology for the position and gesture of the work piece in laser material processing. The method of the electronic parallel datum is to calculate by a stereo angle between the two beams of light with inclination simulating parameters of an object and successfully replace the 6-DOF mechanical datum of the related work piece by being pre-set in the demanding related work piece and system. Furthermore, it is the intelligent direct reading of 6-DOF mechanical datum and parameter storage function of the technique, and greatly improve the benefit performance of the nifty system and at the same time offer the available process control method and can be used for all manufacturing industrial, including the micro-fabrication and micro-manufacturing, etc. It can be used for ultra precision manufacturing environment, because the diameter of the laser beam can reach 100 nm and ion beam diameter even reached the extreme limit precision of 2nm. It is widely used in the intelligent control process and system such as installation and adjustment, and undoubtedly. With the method the useful system will become more precise, run faster and cost less.