A one-pot umpolung method for preparation of α-aryl nitriles from α-chloro aldoximes via organocuprate additions to transient nitrosoalkenes

Ritobroto Sengupta, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Conjugate addition of a variety of aryl lithiocyanocuprates to nitrosoalkenes generated from α-chloro aldoximes, followed by in situ dehydration of the crude α-aryl aldoxime product with N,N- dicyclohexylcarbodiimide, affords α-aryl nitriles in good overall yields via a one-pot protocol.

Original languageEnglish (US)
Pages (from-to)2933-2937
Number of pages5
JournalSynthesis (Germany)
Volume44
Issue number18
DOIs
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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