A one‐pot synthesis of (±)‐(ring 13C6)‐mandelic acid is reported. [Ring 13C6]‐benzaldehyde was cyanosilylated with trimethylsilyl cyanide (TMSCN)/Znl2. The resulting cyanosilylated adduct was hydrolyzed with concentrated hydrochloric acid without purification. The workup involves evaporation to dryness and extraction of the (±)‐(ring 13C6)‐mandelic acid with hot benzene. After one crystallization, the synthesis produced an overall yield of 65% of (±)‐(ring 13C6)‐mandelic acid that was about 98% pure by HPLC with UV detection.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Organic Chemistry