A one‐pot synthesis of (±)‐(ring 13C6)‐mandelic acid

Sarath R. Sirimanne, Donald G. Patterson

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

A one‐pot synthesis of (±)‐(ring 13C6)‐mandelic acid is reported. [Ring 13C6]‐benzaldehyde was cyanosilylated with trimethylsilyl cyanide (TMSCN)/Znl2. The resulting cyanosilylated adduct was hydrolyzed with concentrated hydrochloric acid without purification. The workup involves evaporation to dryness and extraction of the (±)‐(ring 13C6)‐mandelic acid with hot benzene. After one crystallization, the synthesis produced an overall yield of 65% of (±)‐(ring 13C6)‐mandelic acid that was about 98% pure by HPLC with UV detection.

Original languageEnglish (US)
Pages (from-to)725-731
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume33
Issue number8
DOIs
StatePublished - Aug 1993

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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