A perspective on enzyme catalysis

Stephen J. Benkovic, Sharon Hammes-Schiffer

Research output: Contribution to journalReview articlepeer-review

841 Scopus citations

Abstract

The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized. The historical record is explored from both biochemical and theoretical perspectives. Particular attention is given to the impact of molecular motions within the protein on the enzyme's catalytic properties. A case study for the enzyme dihydrofolate reductase provides evidence for coupled networks of predominantly conserved residues that influence the protein structure and motion. Such coupled networks have important implications for the origin and evolution of enzymes, as well as for protein engineering.

Original languageEnglish (US)
Pages (from-to)1196-1202
Number of pages7
JournalScience
Volume301
Issue number5637
DOIs
StatePublished - Aug 29 2003

All Science Journal Classification (ASJC) codes

  • General

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