A phase I study of hepatic arterial infusion using difluoromethylornithine

Allan Lipton, Harold Harvey, Jerry Glenn, William A. Weidner, Melvin Strauss, Sharon E. Miller, Jerlynn B. Taylor, Deborah White‐Hershey, John L.R. Barlow

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m2.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalCancer
Volume63
Issue number3
DOIs
StatePublished - Jan 1 1989

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Eflornithine
Liver
Liver Diseases

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lipton, Allan ; Harvey, Harold ; Glenn, Jerry ; Weidner, William A. ; Strauss, Melvin ; Miller, Sharon E. ; Taylor, Jerlynn B. ; White‐Hershey, Deborah ; Barlow, John L.R. / A phase I study of hepatic arterial infusion using difluoromethylornithine. In: Cancer. 1989 ; Vol. 63, No. 3. pp. 433-437.
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author = "Allan Lipton and Harold Harvey and Jerry Glenn and Weidner, {William A.} and Melvin Strauss and Miller, {Sharon E.} and Taylor, {Jerlynn B.} and Deborah White‐Hershey and Barlow, {John L.R.}",
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Lipton, A, Harvey, H, Glenn, J, Weidner, WA, Strauss, M, Miller, SE, Taylor, JB, White‐Hershey, D & Barlow, JLR 1989, 'A phase I study of hepatic arterial infusion using difluoromethylornithine', Cancer, vol. 63, no. 3, pp. 433-437. https://doi.org/10.1002/1097-0142(19890201)63:3<433::AID-CNCR2820630306>3.0.CO;2-5

A phase I study of hepatic arterial infusion using difluoromethylornithine. / Lipton, Allan; Harvey, Harold; Glenn, Jerry; Weidner, William A.; Strauss, Melvin; Miller, Sharon E.; Taylor, Jerlynn B.; White‐Hershey, Deborah; Barlow, John L.R.

In: Cancer, Vol. 63, No. 3, 01.01.1989, p. 433-437.

Research output: Contribution to journalArticle

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AU - Miller, Sharon E.

AU - Taylor, Jerlynn B.

AU - White‐Hershey, Deborah

AU - Barlow, John L.R.

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AB - Ten patients with metastatic disease to the liver were treated with difluoromethylornithine (DFMO) administered by continuous hepatic arterial infusion. Two of nine evaluable patients had an objective partial response. Stable disease was recorded in three patients. Ototoxicity was encountered in all patients who received a daily dose of DFMO equal to or greater than 1.0 g/m2.

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