A polymorphism in mitochondrial DNA associated with IQ?

Patricia Skuder, Robert Plomin, Gerald E. McClearn, Deborah L. Smith, Sylvia Vignetti, Michael J. Chorney, Karen Chorney, Steven Kasarda, Lee A. Thompson, Douglas K. Detterman, Stephen A. Petrill, Johanna Daniels, Michael J. Owen, Peter McGuffin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In an allelic association study of 100 DNA markers in or near genes of neurological relevance, one restriction fragment length polymorphism (RFLP) yielded significant differences between high- and low-IQ groups in two independent samples. The goal of this article is to describe how we tracked down the specific gene marked by the RFLP and to introduce some current techniques used to apply molecular genetics to complex traits like IQ. The RFLP, EST00083, is a brain-expressed sequence tag site (BESTS) derived from a cDNA hippocampal library. The cDNA clone was shown to involve a chimera between genomic DNA on Chromosome 6 and mitochondrial DNA (mtDNA). The RFLP was localized in the mtDNA rather than the genomic DNA. The RFLP is an Mspl restriction site (CCGG) at 15,925 base pairs of the complete mitochondrial genome in a gene that codes for the transfer RNA for threonine. The mitochondrial origin of the EST00083 RFLP explains why the RFLP is maternally transmitted and never yields heterozygotes. Although mtDNA could be associated with IQ, such an unusual result requires further replication.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalIntelligence
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1995

Fingerprint

Mitochondrial DNA
Restriction Fragment Length Polymorphisms
Genes
Chromosomes, Human, Pair 6
Mitochondrial Genome
DNA
Expressed Sequence Tags
Threonine
Heterozygote
Transfer RNA
Polymorphism
Gene Library
Genetic Markers
Base Pairing
Length
Molecular Biology
Complementary DNA
Clone Cells
Brain
Gene

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Skuder, P., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., ... McGuffin, P. (1995). A polymorphism in mitochondrial DNA associated with IQ? Intelligence, 21(1), 1-11. https://doi.org/10.1016/0160-2896(95)90035-7
Skuder, Patricia ; Plomin, Robert ; McClearn, Gerald E. ; Smith, Deborah L. ; Vignetti, Sylvia ; Chorney, Michael J. ; Chorney, Karen ; Kasarda, Steven ; Thompson, Lee A. ; Detterman, Douglas K. ; Petrill, Stephen A. ; Daniels, Johanna ; Owen, Michael J. ; McGuffin, Peter. / A polymorphism in mitochondrial DNA associated with IQ?. In: Intelligence. 1995 ; Vol. 21, No. 1. pp. 1-11.
@article{d74d2fa5e3144707b4cbd939cc7e3228,
title = "A polymorphism in mitochondrial DNA associated with IQ?",
abstract = "In an allelic association study of 100 DNA markers in or near genes of neurological relevance, one restriction fragment length polymorphism (RFLP) yielded significant differences between high- and low-IQ groups in two independent samples. The goal of this article is to describe how we tracked down the specific gene marked by the RFLP and to introduce some current techniques used to apply molecular genetics to complex traits like IQ. The RFLP, EST00083, is a brain-expressed sequence tag site (BESTS) derived from a cDNA hippocampal library. The cDNA clone was shown to involve a chimera between genomic DNA on Chromosome 6 and mitochondrial DNA (mtDNA). The RFLP was localized in the mtDNA rather than the genomic DNA. The RFLP is an Mspl restriction site (CCGG) at 15,925 base pairs of the complete mitochondrial genome in a gene that codes for the transfer RNA for threonine. The mitochondrial origin of the EST00083 RFLP explains why the RFLP is maternally transmitted and never yields heterozygotes. Although mtDNA could be associated with IQ, such an unusual result requires further replication.",
author = "Patricia Skuder and Robert Plomin and McClearn, {Gerald E.} and Smith, {Deborah L.} and Sylvia Vignetti and Chorney, {Michael J.} and Karen Chorney and Steven Kasarda and Thompson, {Lee A.} and Detterman, {Douglas K.} and Petrill, {Stephen A.} and Johanna Daniels and Owen, {Michael J.} and Peter McGuffin",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0160-2896(95)90035-7",
language = "English (US)",
volume = "21",
pages = "1--11",
journal = "Intelligence",
issn = "0160-2896",
publisher = "Elsevier Limited",
number = "1",

}

Skuder, P, Plomin, R, McClearn, GE, Smith, DL, Vignetti, S, Chorney, MJ, Chorney, K, Kasarda, S, Thompson, LA, Detterman, DK, Petrill, SA, Daniels, J, Owen, MJ & McGuffin, P 1995, 'A polymorphism in mitochondrial DNA associated with IQ?', Intelligence, vol. 21, no. 1, pp. 1-11. https://doi.org/10.1016/0160-2896(95)90035-7

A polymorphism in mitochondrial DNA associated with IQ? / Skuder, Patricia; Plomin, Robert; McClearn, Gerald E.; Smith, Deborah L.; Vignetti, Sylvia; Chorney, Michael J.; Chorney, Karen; Kasarda, Steven; Thompson, Lee A.; Detterman, Douglas K.; Petrill, Stephen A.; Daniels, Johanna; Owen, Michael J.; McGuffin, Peter.

In: Intelligence, Vol. 21, No. 1, 01.01.1995, p. 1-11.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A polymorphism in mitochondrial DNA associated with IQ?

AU - Skuder, Patricia

AU - Plomin, Robert

AU - McClearn, Gerald E.

AU - Smith, Deborah L.

AU - Vignetti, Sylvia

AU - Chorney, Michael J.

AU - Chorney, Karen

AU - Kasarda, Steven

AU - Thompson, Lee A.

AU - Detterman, Douglas K.

AU - Petrill, Stephen A.

AU - Daniels, Johanna

AU - Owen, Michael J.

AU - McGuffin, Peter

PY - 1995/1/1

Y1 - 1995/1/1

N2 - In an allelic association study of 100 DNA markers in or near genes of neurological relevance, one restriction fragment length polymorphism (RFLP) yielded significant differences between high- and low-IQ groups in two independent samples. The goal of this article is to describe how we tracked down the specific gene marked by the RFLP and to introduce some current techniques used to apply molecular genetics to complex traits like IQ. The RFLP, EST00083, is a brain-expressed sequence tag site (BESTS) derived from a cDNA hippocampal library. The cDNA clone was shown to involve a chimera between genomic DNA on Chromosome 6 and mitochondrial DNA (mtDNA). The RFLP was localized in the mtDNA rather than the genomic DNA. The RFLP is an Mspl restriction site (CCGG) at 15,925 base pairs of the complete mitochondrial genome in a gene that codes for the transfer RNA for threonine. The mitochondrial origin of the EST00083 RFLP explains why the RFLP is maternally transmitted and never yields heterozygotes. Although mtDNA could be associated with IQ, such an unusual result requires further replication.

AB - In an allelic association study of 100 DNA markers in or near genes of neurological relevance, one restriction fragment length polymorphism (RFLP) yielded significant differences between high- and low-IQ groups in two independent samples. The goal of this article is to describe how we tracked down the specific gene marked by the RFLP and to introduce some current techniques used to apply molecular genetics to complex traits like IQ. The RFLP, EST00083, is a brain-expressed sequence tag site (BESTS) derived from a cDNA hippocampal library. The cDNA clone was shown to involve a chimera between genomic DNA on Chromosome 6 and mitochondrial DNA (mtDNA). The RFLP was localized in the mtDNA rather than the genomic DNA. The RFLP is an Mspl restriction site (CCGG) at 15,925 base pairs of the complete mitochondrial genome in a gene that codes for the transfer RNA for threonine. The mitochondrial origin of the EST00083 RFLP explains why the RFLP is maternally transmitted and never yields heterozygotes. Although mtDNA could be associated with IQ, such an unusual result requires further replication.

UR - http://www.scopus.com/inward/record.url?scp=0001454025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001454025&partnerID=8YFLogxK

U2 - 10.1016/0160-2896(95)90035-7

DO - 10.1016/0160-2896(95)90035-7

M3 - Article

AN - SCOPUS:0001454025

VL - 21

SP - 1

EP - 11

JO - Intelligence

JF - Intelligence

SN - 0160-2896

IS - 1

ER -

Skuder P, Plomin R, McClearn GE, Smith DL, Vignetti S, Chorney MJ et al. A polymorphism in mitochondrial DNA associated with IQ? Intelligence. 1995 Jan 1;21(1):1-11. https://doi.org/10.1016/0160-2896(95)90035-7