A Precision Medicine Approach to Improve Cancer Rehabilitation’s Impact and Integration with Cancer Care and Optimize Patient Wellness

Catherine M. Alfano, David S. Zucker, Mackenzi Pergolotti, Kirsten K. Ness, Lee W. Jones, Nathan D. Price, Kathryn H. Schmitz, Jennifer A. Ligibel

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Many patients treated for cancer develop toxicities that go unaddressed, limiting their functioning, health, quality of life, and ability to work. This review describes how to optimize patient functioning and quality of life by preventing toxicities where possible or treating them early to reduce impairment and prevent disability. Recent Findings: Increasing the impact of cancer rehabilitation on preventing and treating toxicity requires filling research gaps and better integrating rehabilitation with cancer care. Summary: We must understand risk factors and the underlying biology driving impairments, disability, and individual response to intervention. Then, we need to integrate these data and implement screening of all patients throughout treatment and beyond to (1) monitor biological changes that would lead to downstream impairments and facilitate referrals for personalized rehabilitation interventions to prevent these; (2) where prevention is impossible, screen for impairments and prescribe interventions to treat them early; or (3) intervene to prevent disability resulting from impairments that cannot be prevented or treated.

Original languageEnglish (US)
Pages (from-to)64-73
Number of pages10
JournalCurrent Physical Medicine and Rehabilitation Reports
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2017

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Orthopedics and Sports Medicine
  • Medicine (miscellaneous)

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