A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii

Jianxun Song, X. Wang, F. Huang, C. Feng, Z. Zhang, Y. Huo, Q. Pang

Research output: Contribution to journalArticle

Abstract

Target-primaquine (TPQ)--the primaquine entrapped by galactosylneoglycoalbumin (G-NGA), was given intravenously (iv) to Wistar rats 2 h after sporozoite inoculation. The sporozoite viability (SPV) of TPQ 20 mg/kg group was revealed to be 1.2% 42 h after inoculation, which showed a decline of about 6% as compared to the control; besides, degeneration or retardation of development was present in 90% of EEF. In TPQ 10 mg/kg and PQ 20 mg/kg groups, the SPV were 2.8% and 5.0%, respectively, showing drops by 15% and 26% as compared with that of the control. Degeneration or retardation in development was also visible in about half of the EEF. In mice which were treated iv with TPQ 10 mg/kg or PQ 20 mg/kg 2 h after sporozoite inoculation, the prepatent periods were delayed markedly as compared with that of the control. Parasitemia did not appear in 2 mice in 10 mg/kg TPQ group further indicated the effectiveness of the drug. The results suggest that the anti-EEF effect of TPQ is apparently more promising than that of PQ.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalZhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Volume13
Issue number2
StatePublished - Jan 1 1995

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Plasmodium yoelii
Primaquine
Sporozoites
Parasitemia
Wistar Rats

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii",
abstract = "Target-primaquine (TPQ)--the primaquine entrapped by galactosylneoglycoalbumin (G-NGA), was given intravenously (iv) to Wistar rats 2 h after sporozoite inoculation. The sporozoite viability (SPV) of TPQ 20 mg/kg group was revealed to be 1.2{\%} 42 h after inoculation, which showed a decline of about 6{\%} as compared to the control; besides, degeneration or retardation of development was present in 90{\%} of EEF. In TPQ 10 mg/kg and PQ 20 mg/kg groups, the SPV were 2.8{\%} and 5.0{\%}, respectively, showing drops by 15{\%} and 26{\%} as compared with that of the control. Degeneration or retardation in development was also visible in about half of the EEF. In mice which were treated iv with TPQ 10 mg/kg or PQ 20 mg/kg 2 h after sporozoite inoculation, the prepatent periods were delayed markedly as compared with that of the control. Parasitemia did not appear in 2 mice in 10 mg/kg TPQ group further indicated the effectiveness of the drug. The results suggest that the anti-EEF effect of TPQ is apparently more promising than that of PQ.",
author = "Jianxun Song and X. Wang and F. Huang and C. Feng and Z. Zhang and Y. Huo and Q. Pang",
year = "1995",
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journal = "Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases",
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publisher = "Zhongguo Yufang Yixue Kexueyuan",
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A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii. / Song, Jianxun; Wang, X.; Huang, F.; Feng, C.; Zhang, Z.; Huo, Y.; Pang, Q.

In: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, Vol. 13, No. 2, 01.01.1995, p. 117-119.

Research output: Contribution to journalArticle

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T1 - A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii

AU - Song, Jianxun

AU - Wang, X.

AU - Huang, F.

AU - Feng, C.

AU - Zhang, Z.

AU - Huo, Y.

AU - Pang, Q.

PY - 1995/1/1

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