A prospective randomized study of glutamine-enriched parenteral compared with enteral feeding in postoperative patients

Judith Fish, George Sporay, Karen Beyer, John Jones, Todd Kihara, Alfred Kennedy, Caroline Apovian, Gordon Lee Jensen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Plasma amino acids were measured in 17 postoperative subjects randomly assigned to receive for ≤ 5 d tube feeding or total parenteral nutrition (TPN) that had identical energy, nitrogen, and glutamine contents. Subjects required gastric or pancreatic surgery for malignancy and were well-matched for age and body mass index. Tube feeding or TPN began on postoperative day 1 and advanced in daily 25% increments to meet goals of 105 kJ·kg body wt - 1 ·d -1 , 1.5 g protein·kg body wt -1 ·d -1 , and 0.3 g glutamine·kg body wt -1 ·d -1 . Delivered energy, nitrogen, and glutamine were closely matched on day 4. Nitrogen balance and plasma proteins did not differ significantly between feeding groups. Total indispensable amino acids, branched-chain amino acids, and glutamine declined 25% on postoperative day 1 compared with preoperative day 0. Indispensable and branched-chain amino acid concentrations were restored with 5 d of either tube feeding or TPN. Glutamine concentrations did not differ significantly by feeding group, though a trend suggested that glutamine recovered more slowly in the tube- fed than in the TPN-fed subjects. Plasma amino acids otherwise reflected formula composition with ratios of valine to leucine of 1.24 and 3.69 μmol/L in subjects receiving 5 d of tube feeding or TPN, respectively. These findings suggest that glutamine-enriched tube feeding and TPN can result in similar profiles for most plasma amino acids at carefully matched doses.

Original languageEnglish (US)
Pages (from-to)977-983
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume65
Issue number4
DOIs
StatePublished - Jan 1 1997

Fingerprint

Total Parenteral Nutrition
Enteral Nutrition
Glutamine
Prospective Studies
Amino Acids
Branched Chain Amino Acids
Nitrogen
Valine
Leucine
Blood Proteins
Stomach
Body Mass Index
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fish, Judith ; Sporay, George ; Beyer, Karen ; Jones, John ; Kihara, Todd ; Kennedy, Alfred ; Apovian, Caroline ; Jensen, Gordon Lee. / A prospective randomized study of glutamine-enriched parenteral compared with enteral feeding in postoperative patients. In: American Journal of Clinical Nutrition. 1997 ; Vol. 65, No. 4. pp. 977-983.
@article{6f89e33cd27a429183edf9945d453dc4,
title = "A prospective randomized study of glutamine-enriched parenteral compared with enteral feeding in postoperative patients",
abstract = "Plasma amino acids were measured in 17 postoperative subjects randomly assigned to receive for ≤ 5 d tube feeding or total parenteral nutrition (TPN) that had identical energy, nitrogen, and glutamine contents. Subjects required gastric or pancreatic surgery for malignancy and were well-matched for age and body mass index. Tube feeding or TPN began on postoperative day 1 and advanced in daily 25{\%} increments to meet goals of 105 kJ·kg body wt - 1 ·d -1 , 1.5 g protein·kg body wt -1 ·d -1 , and 0.3 g glutamine·kg body wt -1 ·d -1 . Delivered energy, nitrogen, and glutamine were closely matched on day 4. Nitrogen balance and plasma proteins did not differ significantly between feeding groups. Total indispensable amino acids, branched-chain amino acids, and glutamine declined 25{\%} on postoperative day 1 compared with preoperative day 0. Indispensable and branched-chain amino acid concentrations were restored with 5 d of either tube feeding or TPN. Glutamine concentrations did not differ significantly by feeding group, though a trend suggested that glutamine recovered more slowly in the tube- fed than in the TPN-fed subjects. Plasma amino acids otherwise reflected formula composition with ratios of valine to leucine of 1.24 and 3.69 μmol/L in subjects receiving 5 d of tube feeding or TPN, respectively. These findings suggest that glutamine-enriched tube feeding and TPN can result in similar profiles for most plasma amino acids at carefully matched doses.",
author = "Judith Fish and George Sporay and Karen Beyer and John Jones and Todd Kihara and Alfred Kennedy and Caroline Apovian and Jensen, {Gordon Lee}",
year = "1997",
month = "1",
day = "1",
doi = "10.1093/ajcn/65.4.977",
language = "English (US)",
volume = "65",
pages = "977--983",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "4",

}

A prospective randomized study of glutamine-enriched parenteral compared with enteral feeding in postoperative patients. / Fish, Judith; Sporay, George; Beyer, Karen; Jones, John; Kihara, Todd; Kennedy, Alfred; Apovian, Caroline; Jensen, Gordon Lee.

In: American Journal of Clinical Nutrition, Vol. 65, No. 4, 01.01.1997, p. 977-983.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A prospective randomized study of glutamine-enriched parenteral compared with enteral feeding in postoperative patients

AU - Fish, Judith

AU - Sporay, George

AU - Beyer, Karen

AU - Jones, John

AU - Kihara, Todd

AU - Kennedy, Alfred

AU - Apovian, Caroline

AU - Jensen, Gordon Lee

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Plasma amino acids were measured in 17 postoperative subjects randomly assigned to receive for ≤ 5 d tube feeding or total parenteral nutrition (TPN) that had identical energy, nitrogen, and glutamine contents. Subjects required gastric or pancreatic surgery for malignancy and were well-matched for age and body mass index. Tube feeding or TPN began on postoperative day 1 and advanced in daily 25% increments to meet goals of 105 kJ·kg body wt - 1 ·d -1 , 1.5 g protein·kg body wt -1 ·d -1 , and 0.3 g glutamine·kg body wt -1 ·d -1 . Delivered energy, nitrogen, and glutamine were closely matched on day 4. Nitrogen balance and plasma proteins did not differ significantly between feeding groups. Total indispensable amino acids, branched-chain amino acids, and glutamine declined 25% on postoperative day 1 compared with preoperative day 0. Indispensable and branched-chain amino acid concentrations were restored with 5 d of either tube feeding or TPN. Glutamine concentrations did not differ significantly by feeding group, though a trend suggested that glutamine recovered more slowly in the tube- fed than in the TPN-fed subjects. Plasma amino acids otherwise reflected formula composition with ratios of valine to leucine of 1.24 and 3.69 μmol/L in subjects receiving 5 d of tube feeding or TPN, respectively. These findings suggest that glutamine-enriched tube feeding and TPN can result in similar profiles for most plasma amino acids at carefully matched doses.

AB - Plasma amino acids were measured in 17 postoperative subjects randomly assigned to receive for ≤ 5 d tube feeding or total parenteral nutrition (TPN) that had identical energy, nitrogen, and glutamine contents. Subjects required gastric or pancreatic surgery for malignancy and were well-matched for age and body mass index. Tube feeding or TPN began on postoperative day 1 and advanced in daily 25% increments to meet goals of 105 kJ·kg body wt - 1 ·d -1 , 1.5 g protein·kg body wt -1 ·d -1 , and 0.3 g glutamine·kg body wt -1 ·d -1 . Delivered energy, nitrogen, and glutamine were closely matched on day 4. Nitrogen balance and plasma proteins did not differ significantly between feeding groups. Total indispensable amino acids, branched-chain amino acids, and glutamine declined 25% on postoperative day 1 compared with preoperative day 0. Indispensable and branched-chain amino acid concentrations were restored with 5 d of either tube feeding or TPN. Glutamine concentrations did not differ significantly by feeding group, though a trend suggested that glutamine recovered more slowly in the tube- fed than in the TPN-fed subjects. Plasma amino acids otherwise reflected formula composition with ratios of valine to leucine of 1.24 and 3.69 μmol/L in subjects receiving 5 d of tube feeding or TPN, respectively. These findings suggest that glutamine-enriched tube feeding and TPN can result in similar profiles for most plasma amino acids at carefully matched doses.

UR - http://www.scopus.com/inward/record.url?scp=0031001940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031001940&partnerID=8YFLogxK

U2 - 10.1093/ajcn/65.4.977

DO - 10.1093/ajcn/65.4.977

M3 - Article

C2 - 9094882

AN - SCOPUS:0031001940

VL - 65

SP - 977

EP - 983

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -