A randomized controlled prospective outcome study of a psychological and pharmacological intervention protocol for procedural distress in pediatric leukemia

Anne E. Kazak, Biancamaria Penati, Bret A. Boyer, Bruce Himelstein, Patricia Brophy, Mary Katherine Waibel, George F. Blackall, Ruth Daller, Kelly Johnson

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101 Scopus citations

Abstract

Evaluated distress during invasive procedures in childhood leukemia. Child and parent distress, assessed by questionnaires and ratings, were compared in two arms of a randomized, controlled prospective study, one a pharmacologic only (PO) (n = 45) and the other a combined pharmacologic and psychological intervention (CI) (n = 47), at 1, 2, and 6 months after diagnosis. The cross-sectional control group (CC) consisted of parents of 70 patients in first remission prior to the prospective study. Mothers' and nurses' ratings of child distress indicated less child distress in the CI group than the PO. When contrasted with the CC group, the CI group showed lower levels of child distress. Data showed decreases over time in distress and concurrent improvements in quality of life and parenting stress and supported an inverse association between distress and child age.

Original languageEnglish (US)
Pages (from-to)615-631
Number of pages17
JournalJournal of pediatric psychology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 1996

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

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