A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum

W. J. Hurst, Ian Zagon, H. Y. Aboul-Enein

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

HPLC with UV and electrochemical detection has routinely been employed for the determination of the opioid antagonist naltrexone in serum. Sample preparation protocols range from liquid/liquid to solid phase extraction. The sample preparation described in this communication uses ultrafiltration as the mode of sample preparation prior to HPLC analysis. The method is accurate, precise and saves considerable time compared to previously published techniques.

Original languageEnglish (US)
Pages (from-to)595-596
Number of pages2
JournalDie Pharmazie
Volume54
Issue number8
StatePublished - 1999

Fingerprint

Naltrexone
Narcotic Antagonists
High Pressure Liquid Chromatography
Solid Phase Extraction
Ultrafiltration
Liquids
Serum
Communication

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

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A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum. / Hurst, W. J.; Zagon, Ian; Aboul-Enein, H. Y.

In: Die Pharmazie, Vol. 54, No. 8, 1999, p. 595-596.

Research output: Contribution to journalArticle

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