A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

J. J. Drabick, V. L. Horning, J. L. Lennox, P. E. Coyne, C. N. Oster, R. D. Knight, T. A. Dillard, S. A. Fuller, J. J. Damato, D. S. Burke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.

Original languageEnglish (US)
Pages (from-to)93-94
Number of pages2
JournalMilitary medicine
Issue number2
StatePublished - 1991

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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