A retrospective study of elevated post-operative parathormone in primary hyperparathyroid patients

Shaobo Cao, Ya Hu, Yiming Zhao, Zhe Su, Zhiyan Xu, Xiang Gao, Quan Liao, Yupei Zhao

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We retrospectively analyzed the relationship between normocalcemic parathormone elevation (NPE) and recurrence of primary hyperparathyroidism (pHPT) after surgery, as well as the risk factors of NPE. Out of 309 patients with pHPT that underwent parathyroidectomy. Six months after surgery, 75 patients exhibited NPE with high preoperative serum levels of alkaline phosphatase, calcium and intact parathyroid hormone (iPTH), postoperative day 1 iPTH, and large parathyroid volume. 15 exhibited NPE at 2 years after surgery with low serum vitamin D levels. Postoperative serum iPTH levels gradually normalized in most patients. Multivariate analysis showed that male patients were at greater risk for postoperative NPE (p < 0.05). Only 3 of 309 patients showed recurrence during the follow-up period. NPE may not predict recurrent hyperparathyroidism or incomplete parathyroidectomy for benign parathyroid lesions. Postoperative NPE thus appears to be a response to severe hyperparathyroidism and vitamin D deficiency.

Original languageEnglish (US)
Pages (from-to)101158-101164
Number of pages7
JournalOncotarget
Volume8
Issue number60
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology

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