A review of HELLP syndrome

William M. Curtin, Louis Weinstein

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a variant of severe preeclampsia which is associated with substantial maternal and perinatal morbidity and mortality. As with preeclampsia, the etiology and pathogenesis of HELLP syndrome is not completely understood. An increase in vascular thrombosis and activation of the coagulation system may be important in the clinical presentation of this disorder. Laboratory criteria the diagnosis of HELLP syndrome have been classically described but lack uniformity among different institutions. Aggressive management of HELLP syndrome with expeditious delivery appears to yield the lowest perinatal mortality rates. Conservative or expectant management has been associated with higher stillbirth rates with antenatal corticosteroids not causing resolution of the laboratory abnormalities. Resolution of laboratory abnormalities in HELLP syndrome runs a protracted course over several days after delivery. Despite nearly two decades sinse HELLP syndrome has been defined as a clinical entity, treatment for the disorder still remains delivery of the patient.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalJournal of Perinatology
Volume19
Issue number2
DOIs
StatePublished - Mar 1999

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Hemolysis
Blood Platelets
Liver
Enzymes
Perinatal Mortality
Pre-Eclampsia
Stillbirth
Clinical Laboratory Techniques
Blood Vessels
Adrenal Cortex Hormones
Thrombosis
Mothers
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Curtin, William M. ; Weinstein, Louis. / A review of HELLP syndrome. In: Journal of Perinatology. 1999 ; Vol. 19, No. 2. pp. 138-143.
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A review of HELLP syndrome. / Curtin, William M.; Weinstein, Louis.

In: Journal of Perinatology, Vol. 19, No. 2, 03.1999, p. 138-143.

Research output: Contribution to journalReview article

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