A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes

Douglas K. Mayfield, Angela M. Brown, Grier P. Page, W. Timothy Garvey, Mark D. Shriver, George Argyropoulos

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The murine Agouti-Related Protein (mAGRP) is upregulated in obese and diabetic mice and can stimulate hyperphagia when overexpressed in transgenic models. Here we report upstream nucleotide sequences of the human hAGRP gene with putative recognition sites for transcription factors including a site for the STAT transactivators. A polymorphism (-38C→T) was identified in the promoter region and the C/C genotype had significantly higher promoter activity and affinity for transcription factors as tested in periphery- and hypothalamus-derived cell lines. The polymorphic site could affect the expression levels of hAGRP and the high expressing C/C genotype was significantly associated with high BMI and type 2 diabetes in Africans.

Original languageEnglish (US)
Pages (from-to)568-573
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume287
Issue number2
DOIs
StatePublished - Sep 21 2001

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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