A selective delta opioid receptor antagonist based on a stilbene core

Alyssa M. Hartung, Hernan A. Navarro, David F. Wiemer, Jeffrey Neighbors

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Studies of directed ortho metalation reactions on an aromatic substrate with multiple potential directing groups have identified conditions that favor either of two regioisomers. One of these regioisomers has been converted to an analogue of the stilbene pawhuskin A, and been shown to have high selectivity as an antagonist of the delta opioid receptor. Docking studies have suggested that this compound can adopt a conformation similar to naltrindole, a known delta antagonist.

Original languageEnglish (US)
Pages (from-to)5532-5535
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number23
DOIs
StatePublished - Dec 1 2015

Fingerprint

naltrindole
Stilbenes
delta Opioid Receptor
Narcotic Antagonists
Conformations
Substrates
pawhuskin A

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Hartung, Alyssa M. ; Navarro, Hernan A. ; Wiemer, David F. ; Neighbors, Jeffrey. / A selective delta opioid receptor antagonist based on a stilbene core. In: Bioorganic and Medicinal Chemistry Letters. 2015 ; Vol. 25, No. 23. pp. 5532-5535.
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A selective delta opioid receptor antagonist based on a stilbene core. / Hartung, Alyssa M.; Navarro, Hernan A.; Wiemer, David F.; Neighbors, Jeffrey.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 23, 01.12.2015, p. 5532-5535.

Research output: Contribution to journalArticle

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