A semiparametric efficient estimator in case-control studies for gene–environment independent models

Liang Liang, Yanyuan Ma, Raymond J. Carroll

Research output: Contribution to journalArticle

Abstract

Case-controls studies are popular epidemiological designs for detecting gene–environment interactions in the etiology of complex diseases, where the genetic susceptibility and environmental exposures may often be reasonably assumed independent in the source population. Various papers have presented analytical methods exploiting gene–environment independence to achieve better efficiency, all of which require either a rare disease assumption or a distributional assumption on the genetic variables. We relax both assumptions. We construct a semiparametric estimator in case-control studies exploiting gene–environment independence, while the distributions of genetic susceptibility and environmental exposures are both unspecified and the disease rate is assumed unknown and is not required to be close to zero. The resulting estimator is semiparametric efficient and its superiority over prospective logistic regression, the usual analysis in case-control studies, is demonstrated in various numerical illustrations.

Original languageEnglish (US)
Pages (from-to)38-50
Number of pages13
JournalJournal of Multivariate Analysis
Volume173
DOIs
StatePublished - Sep 1 2019

Fingerprint

Efficient Estimator
Case-control Study
Susceptibility
Gene-environment Interaction
Estimator
Logistic Regression
Analytical Methods
Logistics
Model
Unknown
Zero
Independence

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Numerical Analysis
  • Statistics, Probability and Uncertainty

Cite this

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abstract = "Case-controls studies are popular epidemiological designs for detecting gene–environment interactions in the etiology of complex diseases, where the genetic susceptibility and environmental exposures may often be reasonably assumed independent in the source population. Various papers have presented analytical methods exploiting gene–environment independence to achieve better efficiency, all of which require either a rare disease assumption or a distributional assumption on the genetic variables. We relax both assumptions. We construct a semiparametric estimator in case-control studies exploiting gene–environment independence, while the distributions of genetic susceptibility and environmental exposures are both unspecified and the disease rate is assumed unknown and is not required to be close to zero. The resulting estimator is semiparametric efficient and its superiority over prospective logistic regression, the usual analysis in case-control studies, is demonstrated in various numerical illustrations.",
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A semiparametric efficient estimator in case-control studies for gene–environment independent models. / Liang, Liang; Ma, Yanyuan; Carroll, Raymond J.

In: Journal of Multivariate Analysis, Vol. 173, 01.09.2019, p. 38-50.

Research output: Contribution to journalArticle

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