APPROXIMATELY 8.5 per cent of black Americans have sickle-cell trait.1 There has been considerable recent interest in identifying these people so that they can be educated regarding sickle-cell disease and offered genetic counseling. Three screening tests are now available for identifying the presence of sickle hemoglobin in small samples of blood. The sodium metabisulfite sickling preparation2 and the slide elution technic of Yakulis and Heller3 require a microscope to read the results. The solubility test described by Ballard et al.4 has the advantage that it can be done in the field without a microscope but is prohibitively expensive for large.
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