A simple, nonenzymatic method for desialylating polysialylated ganglio- N-tetraose series gangliosides to produce GM1

Cara Lynne Schengrund, Pavol Kováč

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Dowex-50W-H+ was used to catalyze the highly selective desialylation of polysialylated ganglio-N-tetraose series gangliosides to yield primarily GM1. High performance thin-layer chromatographic analysis of recovered lipid indicated that 60-70% of the recovered ganglioside was GM1. Identification of the major product as GM1 was confirmed by proton NMR spectra and lack of sialic acid release by Vibrio cholerae sialidase.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalJournal of Lipid Research
Volume40
Issue number1
StatePublished - Jan 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Cell Biology

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