Dowex-50W-H+ was used to catalyze the highly selective desialylation of polysialylated ganglio-N-tetraose series gangliosides to yield primarily GM1. High performance thin-layer chromatographic analysis of recovered lipid indicated that 60-70% of the recovered ganglioside was GM1. Identification of the major product as GM1 was confirmed by proton NMR spectra and lack of sialic acid release by Vibrio cholerae sialidase.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Lipid Research|
|State||Published - Jan 1999|
All Science Journal Classification (ASJC) codes
- Cell Biology