A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene

David J. Vandenbergh, Michael D. Grant, Virginia Severns

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.

Original languageEnglish (US)
Pages (from-to)319-320
Number of pages2
JournalMolecular and Cellular Probes
Volume17
Issue number6
DOIs
StatePublished - Dec 2003

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Tandem Repeat Sequences
Introns
queuine tRNA-ribosyltransferase
Enzymes
Genes
Dopamine Receptors
Protein Biosynthesis
Human Genome
Base Pairing
Sequence Analysis
Alleles
Binding Sites
queuine

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

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title = "A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene",
abstract = "The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine- transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.",
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A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene. / Vandenbergh, David J.; Grant, Michael D.; Severns, Virginia.

In: Molecular and Cellular Probes, Vol. 17, No. 6, 12.2003, p. 319-320.

Research output: Contribution to journalArticle

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