A single molecule barcode nanobiosensor for dynamic multigene analysis in live cells during tissue morphogenesis and wound healing

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study reports a single molecule barcode nanobiosensor for multigene expression analysis at the single cell level. Using a multispectral single molecule sensing (MSMS) system, the dual-labeled barcode probes can be resolved for single molecule tracking, super-resolution localization, multispectral imaging, and spectral unmixing. We demonstrate multiplex detection at the single molecule level for investigating the interplays between Notch1-Dll4 and Nrf2 signaling in leader cell formation during collective cell migration.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages338-339
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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