A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

Atanu Duttaroy, Anirban Paul, Mukta Kundu, Amy Belton

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

A null mutation for the Sod2 gene, Sod2n283 was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sod n283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

Original languageEnglish (US)
Pages (from-to)2295-2299
Number of pages5
JournalGenetics
Volume165
Issue number4
StatePublished - Dec 2003

All Science Journal Classification (ASJC) codes

  • Genetics

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