A statistical model for the identification of genes governing the incidence of cancer with age

Kiranmoy Das, Rongling Wu

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The cancer incidence increases with age. This epidemiological pattern of cancer incidence can be attributed to molecular and cellular processes of individual subjects. Also, the incidence of cancer with ages can be controlled by genes. Here we present a dynamic statistical model for explaining the epidemiological pattern of cancer incidence based on individual genes that regulate cancer formation and progression. We incorporate the mathematical equations of age-specific cancer incidence into a framework for functional mapping aimed at identifying quantitative trait loci (QTLs) for dynamic changes of a complex trait. The mathematical parameters that specify differences in the curve of cancer incidence among QTL genotypes are estimated within the context of maximum likelihood. The model provides testable quantitative hypotheses about the initiation and duration of genetic expression for QTLs involved in cancer progression. Computer simulation was used to examine the statistical behavior of the model. The model can be used as a tool for explaining the epidemiological pattern of cancer incidence.

Original languageEnglish (US)
Article number7
JournalTheoretical Biology and Medical Modelling
Volume5
DOIs
StatePublished - May 14 2008

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Health Informatics

Fingerprint Dive into the research topics of 'A statistical model for the identification of genes governing the incidence of cancer with age'. Together they form a unique fingerprint.

  • Cite this