A statistical procedure to map high-order epistasis for ccomplex traits

Xiaoming Pang, Zhong Wang, John S. Yap, Jianxin Wang, Junjia Zhu, Wenhao Bo, Yafei Lv, Fang Xu, Tao Zhou, Shaofeng Peng, Dengfeng Shen, Rongling Wu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Genetic interactions or epistasis have been thought to play a pivotal role in shaping the formation, development and evolution of life. Previous work focused on lower-order interactions between a pair of genes, but it is obviously inadequate to explain a ccomplex network of genetic interactions and pathways.We review and assess a statistical model for characterizing high-order epistasis among more than two genes or quantitative trait loci (QTLs) that ccontrol a ccomplex trait. The model includes a series of start-of-the-art standard procedures for estimating and testing the nature and magnitude of QTL interactions. Results from simulation studies and real data analysis warrant the statistical properties of the model and its usefulness in practice. High-order epistatic mapping will provide a routine procedure for charting a detailed picture of the genetic regulation mechanisms underlying the phenotypic variation of ccomplex traits.

Original languageEnglish (US)
Article numberbbs027
Pages (from-to)302-314
Number of pages13
JournalBriefings in bioinformatics
Volume14
Issue number3
DOIs
StatePublished - May 1 2013

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Quantitative Trait Loci
Statistical Models
Genes
Art
Testing

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Molecular Biology

Cite this

Pang, Xiaoming ; Wang, Zhong ; Yap, John S. ; Wang, Jianxin ; Zhu, Junjia ; Bo, Wenhao ; Lv, Yafei ; Xu, Fang ; Zhou, Tao ; Peng, Shaofeng ; Shen, Dengfeng ; Wu, Rongling. / A statistical procedure to map high-order epistasis for ccomplex traits. In: Briefings in bioinformatics. 2013 ; Vol. 14, No. 3. pp. 302-314.
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Pang, X, Wang, Z, Yap, JS, Wang, J, Zhu, J, Bo, W, Lv, Y, Xu, F, Zhou, T, Peng, S, Shen, D & Wu, R 2013, 'A statistical procedure to map high-order epistasis for ccomplex traits', Briefings in bioinformatics, vol. 14, no. 3, bbs027, pp. 302-314. https://doi.org/10.1093/bib/bbs027

A statistical procedure to map high-order epistasis for ccomplex traits. / Pang, Xiaoming; Wang, Zhong; Yap, John S.; Wang, Jianxin; Zhu, Junjia; Bo, Wenhao; Lv, Yafei; Xu, Fang; Zhou, Tao; Peng, Shaofeng; Shen, Dengfeng; Wu, Rongling.

In: Briefings in bioinformatics, Vol. 14, No. 3, bbs027, 01.05.2013, p. 302-314.

Research output: Contribution to journalArticle

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AU - Pang, Xiaoming

AU - Wang, Zhong

AU - Yap, John S.

AU - Wang, Jianxin

AU - Zhu, Junjia

AU - Bo, Wenhao

AU - Lv, Yafei

AU - Xu, Fang

AU - Zhou, Tao

AU - Peng, Shaofeng

AU - Shen, Dengfeng

AU - Wu, Rongling

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AB - Genetic interactions or epistasis have been thought to play a pivotal role in shaping the formation, development and evolution of life. Previous work focused on lower-order interactions between a pair of genes, but it is obviously inadequate to explain a ccomplex network of genetic interactions and pathways.We review and assess a statistical model for characterizing high-order epistasis among more than two genes or quantitative trait loci (QTLs) that ccontrol a ccomplex trait. The model includes a series of start-of-the-art standard procedures for estimating and testing the nature and magnitude of QTL interactions. Results from simulation studies and real data analysis warrant the statistical properties of the model and its usefulness in practice. High-order epistatic mapping will provide a routine procedure for charting a detailed picture of the genetic regulation mechanisms underlying the phenotypic variation of ccomplex traits.

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