A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

E. L. Tolman; L. E. Metzger; L. S. Jefferson

doi:10.1016/0006-291X(70)90502-4

A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

E. L. Tolman, L. E. Metzger, L. S. Jefferson

Department of Cellular and Molecular Physiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of ¹⁴C-alanine and ¹⁴C-lactate to glucose were observed in livers of these rats.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(70)90502-4
State	Published - Oct 23 1970

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(70)90502-4

Cite this

@article{751cdccfb17e4d429950e5600f15c126,

title = "A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats",

abstract = "Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.",

author = "Tolman, {E. L.} and Metzger, {L. E.} and Jefferson, {L. S.}",

year = "1970",

month = oct,

day = "23",

doi = "10.1016/0006-291X(70)90502-4",

language = "English (US)",

volume = "41",

pages = "294--298",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

AU - Tolman, E. L.

AU - Metzger, L. E.

AU - Jefferson, L. S.

PY - 1970/10/23

Y1 - 1970/10/23

N2 - Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.

AB - Production of glucose and urea by livers of hypophysectomized rats was twice that by livers of normal rats when both were perfused with medium containing amino acids at either one or ten times their normal plasma concentrations. This suggested a stimulated rate of gluconeogenesis in the livers of hypophysectomized rats. Increased rates of conversion of 14C-alanine and 14C-lactate to glucose were observed in livers of these rats.

UR - http://www.scopus.com/inward/record.url?scp=0014959916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014959916&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(70)90502-4

DO - 10.1016/0006-291X(70)90502-4

M3 - Article

C2 - 5518161

AN - SCOPUS:0014959916

VL - 41

SP - 294

EP - 298

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -

A stimulated rate of gluconeogenesis in perfused livers of hypophysectomized rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this