A structural and functional perspective of alphavirus replication and assembly

Joyce Jose, Jonathan E. Snyder, Richard Kuhn

Research output: Contribution to journalReview article

155 Citations (Scopus)

Abstract

Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for a considerable number of human and animal diseases. Alphavirus members include Chikungunya virus, Sindbis virus, Semliki Forest virus, the western, eastern and Venezuelan equine encephalitis viruses, and the Ross River virus. Alphaviruses can cause arthritic diseases and encephalitis in humans and animals and continue to be a worldwide threat. The viruses are transmitted by blood-sucking arthropods, and replicate in both arthropod and vertebrate hosts. Alphaviruses form spherical particles (65-70 nm in diameter) with icosahedral symmetry and a triangulation number of four. The icosahedral structures of alphaviruses have been defined to very high resolutions by cryo-electron microscopy and crystallographic studies. In this review, we summarize the major events in alphavirus infection: entry, replication, assembly and budding. We focus on data acquired from structural and functional studies of the alphaviruses. These structural and functional data provide a broader perspective of the virus lifecycle and structure, and allow additional insight into these important viruses.

Original languageEnglish (US)
Pages (from-to)837-856
Number of pages20
JournalFuture microbiology
Volume4
Issue number7
DOIs
StatePublished - Sep 23 2009

Fingerprint

Alphavirus
Arthropods
Viruses
Alphavirus Infections
Ross River virus
Western Equine Encephalitis Viruses
Eastern equine encephalitis virus
Venezuelan Equine Encephalitis Viruses
Chikungunya virus
Semliki forest virus
Sindbis Virus
Cryoelectron Microscopy
Viral Structures
Animal Diseases
Encephalitis
Arthritis
Vertebrates

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Jose, Joyce ; Snyder, Jonathan E. ; Kuhn, Richard. / A structural and functional perspective of alphavirus replication and assembly. In: Future microbiology. 2009 ; Vol. 4, No. 7. pp. 837-856.
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A structural and functional perspective of alphavirus replication and assembly. / Jose, Joyce; Snyder, Jonathan E.; Kuhn, Richard.

In: Future microbiology, Vol. 4, No. 7, 23.09.2009, p. 837-856.

Research output: Contribution to journalReview article

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