A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A J mice

Dietrich Hoffmann, Mirjana V. Djordjevic, Abraham Rivenson, Edith Zang, Dhimant Desai, Shantu Amin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tobacco-specific N-nitrosamines (TSNA) are formed from nicotine and the minor Nicotiana tabacum alkaloids during tobacco processing and tobacco smoking. The TSNA are the most abundant strong carcinogens in smokeless tobacco and in smoke. In this comparative study six TSNA and two major volatile N-nitrosamines of cigarette smoke are assayed for their relative tumorigenicities in strain A J female mice and for their potential to induce lung tumors. N-nitrosodimethylamine was the most potent inducer of lung adenoma in the A J mouse model followed in order of decreasing potencies by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, N-nitrosopyrrolidine, N′-nitrosonornicotine and N′-nitrosoanabasine. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol and 4-(methylnitrosamino)-4-(3-pyridyl)butyric acid were inactive. The relative tumorigenic activities of the tobacco-specific nitrosamines in strain A J mice compare well with the available data for their relative tumorigenic activities in F344 rats and Syrian golden hamsters.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalCancer Letters
Volume71
Issue number1-3
DOIs
StatePublished - Jul 30 1993

Fingerprint

Nitrosamines
Tobacco
Carcinogenesis
Lung
Neoplasms
N'-nitrosonornicotine
Smoke
N-Nitrosopyrrolidine
Smokeless Tobacco
Dimethylnitrosamine
Mesocricetus
Inbred F344 Rats
Nicotine
Alkaloids
Tobacco Products
Carcinogens
Adenoma
Smoking

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Hoffmann, Dietrich ; Djordjevic, Mirjana V. ; Rivenson, Abraham ; Zang, Edith ; Desai, Dhimant ; Amin, Shantu. / A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A J mice. In: Cancer Letters. 1993 ; Vol. 71, No. 1-3. pp. 25-30.
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A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A J mice. / Hoffmann, Dietrich; Djordjevic, Mirjana V.; Rivenson, Abraham; Zang, Edith; Desai, Dhimant; Amin, Shantu.

In: Cancer Letters, Vol. 71, No. 1-3, 30.07.1993, p. 25-30.

Research output: Contribution to journalArticle

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