We have developed and continue to support the Galaxy genomic analysis system . Our main public Galaxy analysis website (Galaxy Main) currently supports close to 30,000 users performing hundreds of thousands of analysis jobs every month. Many academic and commercial institutions around the world operate private Galaxy instances. Our efforts so far have been focused on the development of software that enables any biological researcher to perform complex computational analyses by hiding technical complexities associated with management of underlying programs and high-performance compute infrastructure . As a direct consequence of our initial success we have reached a point where we can no longer sustain the exponential growth of analysis load and associated biological data storage on our public servers. Here we discuss our ongoing efforts and future plans for establishing a sustainable national gateway for the analysis of biological data.