A synaptogenic pacing cell line

Ricardo Silva, Eric Barrett, Jamie Kowal, Ji Sung Kim, Harry Allcock, Roger Gaumond

Research output: Contribution to conferencePaper


The SK-N-BE(2c) is an I-type neuroblastoma that develops a strong pacing electrical response over time. This response is likely the result of a developing interconnected network, such that the regular pacemaker-like firing of individual cells becomes synchronous over time forming a Multi Unit Spikes signal (MUS). Immuno-fluorescence was used to show the presence of pre and postsynaptic markers, suggesting that MUS are the result of networking. Hence this cell line could prove as a useful model for synaptic dopaminergic pacing cell systems.

Original languageEnglish (US)
Number of pages2
StatePublished - Dec 1 2005
Event2nd International IEEE EMBS Conference on Neural Engineering, 2005 - Arlington, VA, United States
Duration: Mar 16 2005Mar 19 2005


Other2nd International IEEE EMBS Conference on Neural Engineering, 2005
CountryUnited States
CityArlington, VA

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Silva, R., Barrett, E., Kowal, J., Kim, J. S., Allcock, H., & Gaumond, R. (2005). A synaptogenic pacing cell line. 260-261. Paper presented at 2nd International IEEE EMBS Conference on Neural Engineering, 2005, Arlington, VA, United States. https://doi.org/10.1109/CNE.2005.1419606