A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

Chiara Sartini; Vladimir Lomivorotov; Antonio Pisano; Hynek Riha; Martina Baiardo Redaelli; Juan Carlos Lopez-Delgado; Marina Pieri; Ludhmila Hajjar; Evgeny Fominskiy; Valery Likhvantsev; Luca Cabrini; Nikola Bradic; Daniele Avancini; Chew Yin Wang; Rosalba Lembo; Maxim Novikov; Gianluca Paternoster; Gordana Gazivoda; Gabriele Alvaro; Agostino Roasio; Chengbin Wang; Luca Severi; Laura Pasin; Paolo Mura; Mario Musu; Simona Silvetti; Carmine Domenico Votta; Alessandro Belletti; Francesco Corradi; Claudia Brusasco; Simona Tamà; Laura Ruggeri; Chow Yen Yong; Daniela Pasero; Giuseppe Mancino; Savino Spadaro; Massimiliano Conte; Rosetta Lobreglio; Diana Di Fraja; Emanuela Saporito; Alessandro D'Amico; Salvatore Sardo; Alessandro Ortalda; Andrey Yavorovskiy; Claudio Riefolo; Fabrizio Monaco; Rinaldo Bellomo; Alberto Zangrillo; Giovanni Landoni

doi:10.1053/j.jvca.2019.03.022

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

Chiara Sartini, Vladimir Lomivorotov, Antonio Pisano, Hynek Riha, Martina Baiardo Redaelli, Juan Carlos Lopez-Delgado, Marina Pieri, Ludhmila Hajjar, Evgeny Fominskiy, Valery Likhvantsev, Luca Cabrini, Nikola Bradic, Daniele Avancini, Chew Yin Wang, Rosalba Lembo, Maxim Novikov, Gianluca Paternoster, Gordana Gazivoda, Gabriele Alvaro, Agostino RoasioChengbin Wang, Luca Severi, Laura Pasin, Paolo Mura, Mario Musu, Simona Silvetti, Carmine Domenico Votta, Alessandro Belletti, Francesco Corradi, Claudia Brusasco, Simona Tamà, Laura Ruggeri, Chow Yen Yong, Daniela Pasero, Giuseppe Mancino, Savino Spadaro, Massimiliano Conte, Rosetta Lobreglio, Diana Di Fraja, Emanuela Saporito, Alessandro D'Amico, Salvatore Sardo, Alessandro Ortalda, Andrey Yavorovskiy, Claudio Riefolo, Fabrizio Monaco, Rinaldo Bellomo, Alberto Zangrillo, Giovanni Landoni

Department of Anesthesiology and Perioperative Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objective: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: Two hundred fifty-one physicians from 46 countries. Interventions: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. Measurements and Main Results: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. Conclusion: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.

Original language	English (US)
Pages (from-to)	2685-2694
Number of pages	10
Journal	Journal of cardiothoracic and vascular anesthesia
Volume	33
Issue number	10
DOIs	https://doi.org/10.1053/j.jvca.2019.03.022
State	Published - Oct 2019

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine
Anesthesiology and Pain Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.jvca.2019.03.022

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Sartini, C., Lomivorotov, V., Pisano, A., Riha, H., Baiardo Redaelli, M., Lopez-Delgado, J. C., Pieri, M., Hajjar, L., Fominskiy, E., Likhvantsev, V., Cabrini, L., Bradic, N., Avancini, D., Wang, C. Y., Lembo, R., Novikov, M., Paternoster, G., Gazivoda, G., Alvaro, G., ... Landoni, G. (2019). A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality. Journal of cardiothoracic and vascular anesthesia, 33(10), 2685-2694. https://doi.org/10.1053/j.jvca.2019.03.022

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title = "A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality",

abstract = "Objective: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: Two hundred fifty-one physicians from 46 countries. Interventions: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. Measurements and Main Results: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. Conclusion: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.",

author = "Chiara Sartini and Vladimir Lomivorotov and Antonio Pisano and Hynek Riha and {Baiardo Redaelli}, Martina and Lopez-Delgado, {Juan Carlos} and Marina Pieri and Ludhmila Hajjar and Evgeny Fominskiy and Valery Likhvantsev and Luca Cabrini and Nikola Bradic and Daniele Avancini and Wang, {Chew Yin} and Rosalba Lembo and Maxim Novikov and Gianluca Paternoster and Gordana Gazivoda and Gabriele Alvaro and Agostino Roasio and Chengbin Wang and Luca Severi and Laura Pasin and Paolo Mura and Mario Musu and Simona Silvetti and Votta, {Carmine Domenico} and Alessandro Belletti and Francesco Corradi and Claudia Brusasco and Simona Tam{\`a} and Laura Ruggeri and Yong, {Chow Yen} and Daniela Pasero and Giuseppe Mancino and Savino Spadaro and Massimiliano Conte and Rosetta Lobreglio and {Di Fraja}, Diana and Emanuela Saporito and Alessandro D'Amico and Salvatore Sardo and Alessandro Ortalda and Andrey Yavorovskiy and Claudio Riefolo and Fabrizio Monaco and Rinaldo Bellomo and Alberto Zangrillo and Giovanni Landoni",

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year = "2019",

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Sartini, C, Lomivorotov, V, Pisano, A, Riha, H, Baiardo Redaelli, M, Lopez-Delgado, JC, Pieri, M, Hajjar, L, Fominskiy, E, Likhvantsev, V, Cabrini, L, Bradic, N, Avancini, D, Wang, CY, Lembo, R, Novikov, M, Paternoster, G, Gazivoda, G, Alvaro, G, Roasio, A, Wang, C, Severi, L, Pasin, L, Mura, P, Musu, M, Silvetti, S, Votta, CD, Belletti, A, Corradi, F, Brusasco, C, Tamà, S, Ruggeri, L, Yong, CY, Pasero, D, Mancino, G, Spadaro, S, Conte, M, Lobreglio, R, Di Fraja, D, Saporito, E, D'Amico, A, Sardo, S, Ortalda, A, Yavorovskiy, A, Riefolo, C, Monaco, F, Bellomo, R, Zangrillo, A & Landoni, G 2019, 'A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality', Journal of cardiothoracic and vascular anesthesia, vol. 33, no. 10, pp. 2685-2694. https://doi.org/10.1053/j.jvca.2019.03.022

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting : Interventions Increasing Mortality. / Sartini, Chiara; Lomivorotov, Vladimir; Pisano, Antonio et al.

In: Journal of cardiothoracic and vascular anesthesia, Vol. 33, No. 10, 10.2019, p. 2685-2694.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting

T2 - Interventions Increasing Mortality

AU - Sartini, Chiara

AU - Lomivorotov, Vladimir

AU - Pisano, Antonio

AU - Riha, Hynek

AU - Baiardo Redaelli, Martina

AU - Lopez-Delgado, Juan Carlos

AU - Pieri, Marina

AU - Hajjar, Ludhmila

AU - Fominskiy, Evgeny

AU - Likhvantsev, Valery

AU - Cabrini, Luca

AU - Bradic, Nikola

AU - Avancini, Daniele

AU - Wang, Chew Yin

AU - Lembo, Rosalba

AU - Novikov, Maxim

AU - Paternoster, Gianluca

AU - Gazivoda, Gordana

AU - Alvaro, Gabriele

AU - Roasio, Agostino

AU - Wang, Chengbin

AU - Severi, Luca

AU - Pasin, Laura

AU - Mura, Paolo

AU - Musu, Mario

AU - Silvetti, Simona

AU - Votta, Carmine Domenico

AU - Belletti, Alessandro

AU - Corradi, Francesco

AU - Brusasco, Claudia

AU - Tamà, Simona

AU - Ruggeri, Laura

AU - Yong, Chow Yen

AU - Pasero, Daniela

AU - Mancino, Giuseppe

AU - Spadaro, Savino

AU - Conte, Massimiliano

AU - Lobreglio, Rosetta

AU - Di Fraja, Diana

AU - Saporito, Emanuela

AU - D'Amico, Alessandro

AU - Sardo, Salvatore

AU - Ortalda, Alessandro

AU - Yavorovskiy, Andrey

AU - Riefolo, Claudio

AU - Monaco, Fabrizio

AU - Bellomo, Rinaldo

AU - Zangrillo, Alberto

AU - Landoni, Giovanni

PY - 2019/10

Y1 - 2019/10

N2 - Objective: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: Two hundred fifty-one physicians from 46 countries. Interventions: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. Measurements and Main Results: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. Conclusion: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.

AB - Objective: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: Two hundred fifty-one physicians from 46 countries. Interventions: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. Measurements and Main Results: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. Conclusion: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.

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DO - 10.1053/j.jvca.2019.03.022

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AN - SCOPUS:85071057270

SN - 1053-0770

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SP - 2685

EP - 2694

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

IS - 10

ER -

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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