A tandem cascade cyclization-electrophilic aromatic substitution: Application in the total synthesis of (+)-angelichalcone

Joseph J. Topczewski, Michael P. Callahan, Jeffrey Neighbors, David F. Wiemer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

(Chemical Equation Presented) When cascade cyclizations initiated by Lewis acid-mediated opening of an epoxide are terminated through reaction with a MOM-protected phenol, a tandem electrophilic aromatic substitution can be obtained. This highly regioselective tandem process has been employed in the first synthesis of (+)-angelichalcone.

Original languageEnglish (US)
Pages (from-to)14630-14631
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number41
DOIs
StatePublished - Oct 21 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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