A topological model for chromatin transcription and a role for nucleosome linkers

Sergei Grigoryev, Igor A. Krasheninnikov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is a good deal of evidence that transcribing RNA polymerase may translocate across nucleosomes without their displacement and (or) rearrangement. A topological model for RNA chain elongation on a nucleosome is considered here. A new mechanism of RNA polymerase translocation is suggested in order to avoid the steric hindrances inherent in the model. It is shown that a transcribed nucleoprotein fiber should be interrupted by protein-free DNA stretches (nucleosome linkers) to allow release of nascent RNA. Possible verificiations and consequences of the model are discussed.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalFEBS Letters
Volume162
Issue number1
DOIs
StatePublished - Oct 3 1983

Fingerprint

Nucleosomes
Transcription
Chromatin
DNA-Directed RNA Polymerases
RNA
Nucleoproteins
Elongation
Fibers
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

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A topological model for chromatin transcription and a role for nucleosome linkers. / Grigoryev, Sergei; Krasheninnikov, Igor A.

In: FEBS Letters, Vol. 162, No. 1, 03.10.1983, p. 1-4.

Research output: Contribution to journalArticle

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