A topological model for chromatin transcription and a role for nucleosome linkers

Sergei A. Grigoryev, Igor A. Krasheninnikov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There is a good deal of evidence that transcribing RNA polymerase may translocate across nucleosomes without their displacement and (or) rearrangement. A topological model for RNA chain elongation on a nucleosome is considered here. A new mechanism of RNA polymerase translocation is suggested in order to avoid the steric hindrances inherent in the model. It is shown that a transcribed nucleoprotein fiber should be interrupted by protein-free DNA stretches (nucleosome linkers) to allow release of nascent RNA. Possible verificiations and consequences of the model are discussed.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalFEBS Letters
Volume162
Issue number1
DOIs
StatePublished - Oct 3 1983

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'A topological model for chromatin transcription and a role for nucleosome linkers'. Together they form a unique fingerprint.

Cite this