A tripartite synapse model in Drosophila

Research output: Contribution to journalArticle

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Abstract

Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.

Original languageEnglish (US)
Article numbere17131
JournalPloS one
Volume6
Issue number2
DOIs
StatePublished - Feb 28 2011

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synapse
Synapses
Drosophila
Neuroglia
neuroglia
Glutamic Acid
Genetic Models
Genes
Gases
Invertebrates
Health
glutamates
Calcium
functional properties
gas exchange
invertebrates
Genome
calcium
genome

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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A tripartite synapse model in Drosophila. / Danjo, Rie; Kawasaki, Fumiko; Ordway, Richard W.

In: PloS one, Vol. 6, No. 2, e17131, 28.02.2011.

Research output: Contribution to journalArticle

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